InterPro : IPR003661

Name  Signal transduction histidine kinase EnvZ-like, dimerisation/phosphoacceptor domain Short Name  EnvZ-like_dim/P
Type  Domain Description  This entry represents the dimerisation and phosphoacceptor domain found in some histidine kinases. Signal transducing histidine kinases are the key elements in two-component signal transduction systems, which control complex processes such as the initiation of development in microorganisms []. Examples of histidine kinases are EnvZ, which plays a central role in osmoregulation []. Histidine kinases usually have an N-terminal ligand-binding domain and a C-terminal kinase domain, but other domains may also be present. The kinase domain is responsible for the autophosphorylation of the histidine with ATP, the phosphotransfer from the kinase to an aspartate of the response regulator, and the phosphotransfer from aspartyl phosphate back to ADP or to water []. The homodimeric domain includes the site of histidine autophosphorylation and phosphate transfer reactions. The structure of the homodimeric domain comprises a closed, four-helical bundle with a left-handed twist, formed by two identical alpha-hairpin subunits.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

14 Found In

Id Name Short Name Type
IPR006290 Heavy metal sensor kinase CztS_silS_copS Family
IPR001294 Phytochrome Phytochrome Family
IPR012129 Phytochrome A/B/C/D/E Phytochrome_A-E Family
IPR017116 Signal transduction histidine kinase, PgtB Sig_transdc_His_kinase_PgtB Family
IPR014310 Signal transduction histidine kinase, phosphate regulon sensor PhoR Sig_transdc_His_kinase_PhoR Family
IPR014265 Signal transduction histidine kinase, PEP-CTERM system, putative Sig_transdc_His_kin_PEP-CTERM Family
IPR014409 Signal transduction histidine kinase, hybrid-type, aerobic respiration control ArcB Sig_transdc_His_kin_hyb_ArcB Family
IPR017055 Signal transduction histidine kinase, DctB (C4-dicarboxylate transport system regulator) Sig_transdc_His_kinase_DctB Family
IPR017181 Signal transduction histidine kinase, CHASE2/PAS sensor domain-containing, predicted Sig_transdc_His_kin_CHASE2_PAS Family
IPR017232 Signal transduction histidine kinase, nitrogen fixation and metabolism regulator Sig_transdc_His_kinase_NtrY Family
IPR014302 Signal transduction histidine kinase, TMAO sensor TorS Sig_transdc_His_kinase_TorS Family
IPR014525 Signal transduction histidine kinase, hybrid-type, ethylene sensor Sig_transdc_His_kin_hyb_Et-sen Family
IPR022510 Sortase system, histidine kinase Sortase_His-kinase Family
IPR008358 Signal transduction histidine kinase/phosphatase, lantibiotic regulatory protein MprB Sig_transdc_His_kin/Pase_MprB Family

1 Parent Features

Id Name Short Name Type
IPR009082 Signal transduction histidine kinase, homodimeric domain Sig_transdc_His_kinase_dimeric Domain

3 Publications

First Author Title Year Journal Volume Pages
Perego M Protein aspartate phosphatases control the output of two-component signal transduction systems. 1996 Trends Genet 12 97-101
Tomomori C Solution structure of the homodimeric core domain of Escherichia coli histidine kinase EnvZ. 1999 Nat Struct Biol 6 729-34
Vierstra RD Bacteriophytochromes: new tools for understanding phytochrome signal transduction. 2000 Semin Cell Dev Biol 11 511-21

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)