InterPro : IPR019817

Name  Interferon regulatory factor, conserved site Short Name  Interferon_reg_fac_CS
Type  Conserved_site Description  The expression of type I interferon genes (interferons alpha and beta) is induced by many agents, including viral attack []. Induction is mediated by the binding of interferon regulatory factor 1 (IRF-1) to a region known as the interferon consensus sequence (ICS), located upstream of the interferon genes []. Other factors may also bind to the ICS, including IRF-2, which does not function as an activator, but rather suppresses the function of IRF-1 under certain circumstances []. IRF proteins contain a conserved N-terminal DNA-binding region of about 120 amino acids, which folds into a structure that binds specifically to the ICS; the remaining parts of the sequences vary depending on the precise function of the protein []. This region contains five conserved tryptophans and is known as a 'tryptophan pentad repeat'. The signature of this entry spans the region from the second to the fourth of the five conserved tryptophans.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

3 Found In

Id Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain
IPR001346 Interferon regulatory factor DNA-binding domain Interferon_reg_fact_DNA-bd_dom Domain
IPR017431 Interferon regulatory factor-1/2 Interferon_reg_fac-1/2 Family

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Miyamoto M Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements. 1988 Cell 54 903-13
Harada H Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. 1989 Cell 58 729-39
Weisz A Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes. 1992 J Biol Chem 267 25589-96

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)