InterPro : IPR019817

Name  Interferon regulatory factor, conserved site Short Name  Interferon_reg_fac_CS
Type  Conserved_site Description  The expression of type I interferon genes (interferons alpha and beta) is induced by many agents, including viral attack []. Induction is mediated by the binding of interferon regulatory factor 1 (IRF-1) to a region known as the interferon consensus sequence (ICS), located upstream of the interferon genes []. Other factors may also bind to the ICS, including IRF-2, which does not function as an activator, but rather suppresses the function of IRF-1 under certain circumstances []. IRF proteins contain a conserved N-terminal DNA-binding region of about 120 amino acids, which folds into a structure that binds specifically to the ICS; the remaining parts of the sequences vary depending on the precise function of the protein []. This region contains five conserved tryptophans and is known as a 'tryptophan pentad repeat'. The signature of this entry spans the region from the second to the fourth of the five conserved tryptophans.
 Feedback

Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

0 Contains

3 Found In

Id Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain
IPR001346 Interferon regulatory factor DNA-binding domain Interferon_reg_fact_DNA-bd_dom Domain
IPR017431 Interferon regulatory factor-1/2 Interferon_reg_fac-1/2 Family

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Miyamoto M Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements. 1988 Cell 54 903-13
Harada H Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. 1989 Cell 58 729-39
Weisz A Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes. 1992 J Biol Chem 267 25589-96



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)