InterPro : IPR028977

Name  CD81 antigen, large extracellular loop domain Short Name  CD81_LEL
Type  Domain Description  Human CD81 is a transmembrane protein belonging to the tetraspanin family, whose members are characterised by four hydrophobic transmembrane regions (TM1-4) and two extracellular domains, known as large and small extracellular loops (LEL and SEL, respectively). This entry represents the LEL domain, which is topologically located between TM3 and 4 and contains four invariant Cys residues, two of which define a conserved Cys-Cys-Gly motif []. The key structural features are conserved within the family.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

0 Found In

1 Parent Features

Id Name Short Name Type
IPR008952 Tetraspanin, EC2 domain Tetraspanin_EC2 Domain

1 Publications

First Author Title Year Journal Volume Pages
Kitadokoro K CD81 extracellular domain 3D structure: insight into the tetraspanin superfamily structural motifs. 2001 EMBO J 20 12-8

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)