InterPro : IPR011186

Name  DNA mismatch repair protein Mlh1/HexB Short Name  DNA_mismatch_repair_MLH1/HexB
Type  Family Description  Mismatch repair is one of five major DNA repair pathways, the others being homologous recombination repair, non-homologous end joining, nucleotide excision repair, and base excision repair. The mismatch repair system recognises and repairs mispaired or unpaired nucleotides that result from errors in DNA replication. Many proteins involved in the different repair processes also play a role in apoptosis when DNA damage is excessive, thereby helping to prevent carcinogenesis [].The mismatch repair protein, Mlh1 (mutL homologue 1), has a dual role in DNA repair and apoptosis. Mlh1 acts as a heterodimer in conjunction with Pms2, Pms1 (post-meiotic segregation 1 and 2) or Mlh3 (MutL homologue 3), which function as adaptor proteins that link Msh (MutS homologue) heterodimers to the DNA repair machinery, resulting in excision and repair of the mispaired base []. The HexB repair protein is homologous to the MutL protein. HexB-like proteins are found amongst procaryotic and eucaryotic organisms [].
 Feedback

Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

3 Contains

Id Name Short Name Type
IPR020568 Ribosomal protein S5 domain 2-type fold Ribosomal_S5_D2-typ_fold Domain
IPR003594 Histidine kinase-like ATPase, C-terminal domain HATPase_C Domain
IPR013507 DNA mismatch repair protein, C-terminal DNA_mismatch_repair_C Domain

0 Found In

1 Parent Features

Id Name Short Name Type
IPR002099 DNA mismatch repair protein family DNA_mismatch_repair_fam Family

3 Publications

First Author Title Year Journal Volume Pages
Bernstein C DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis. 2002 Mutat Res 511 145-78
Drotschmann K DNA binding properties of the yeast Msh2-Msh6 and Mlh1-Pms1 heterodimers. 2002 Biol Chem 383 969-75
Prudhomme M Nucleotide sequence of the Streptococcus pneumoniae hexB mismatch repair gene: homology of HexB to MutL of Salmonella typhimurium and to PMS1 of Saccharomyces cerevisiae. 1989 J Bacteriol 171 5332-8



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)