InterPro : IPR010971

Name  Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/UbiI/COQ6 Short Name  Ubi_Hdrxlases
Type  Family Description  This entry represents a family of FAD-dependent hydroxylases (monooxygenases), which are all believed to act in the aerobic ubiquinone biosynthesis pathway []. In Escherichia coli, three enzyme activities have been described: UbiI, UbiH and UbiF []. UbiH and UbiF are similar to one another and form the basis of this subfamily. UbiI (also known as visC) []is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (also known as visB) []. Several other species appear to have three homologues in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homologue in this subfamily (COQ6, []) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



2 Child Features

Id Name Short Name Type
IPR000689 Ubiquinone biosynthesis monooxygenase, COQ6-type UbQ_biosynth_mOase Family
IPR011295 2-polyprenyl-6-methoxyphenol 4-hydroxylase UbiH Family

2 Contains

Id Name Short Name Type
IPR006076 FAD dependent oxidoreductase FAD-dep_OxRdtase Domain
IPR018168 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6, conserved site Ubi_Hdrlase_CS Conserved_site

0 Found In

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Gin P The Saccharomyces cerevisiae COQ6 gene encodes a mitochondrial flavin-dependent monooxygenase required for coenzyme Q biosynthesis. 2003 J Biol Chem 278 25308-16
Meganathan R Ubiquinone biosynthesis in microorganisms. 2001 FEMS Microbiol Lett 203 131-9
Hajj Chehade M ubiI, a new gene in Escherichia coli coenzyme Q biosynthesis, is involved in aerobic C5-hydroxylation. 2013 J Biol Chem 288 20085-92
Nakahigashi K Isolation and characterization of a light-sensitive mutant of Escherichia coli K-12 with a mutation in a gene that is required for the biosynthesis of ubiquinone. 1992 J Bacteriol 174 7352-9

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)