InterPro : IPR006203

Name  GHMP kinase, ATP-binding, conserved site Short Name  GHMP_knse_ATP-bd_CS
Type  Conserved_site Description  The galacto- (), homoserine (), mevalonate () and phosphomevalonate () kinases contain, in their N-terminal section, a conserved Gly/Ser-rich region which is probably involved in the binding of ATP [, ]. This group of kinases has been called 'GHMP' (from the first letter of their substrates).This site is also found in some diphosphomevalonate decarboxylases, which are structurally related members of the GHMP superfamily [], but do not possess kinase activity.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

7 Found In

Id Name Short Name Type
IPR020568 Ribosomal protein S5 domain 2-type fold Ribosomal_S5_D2-typ_fold Domain
IPR006206 Mevalonate/galactokinase Mevalonate/galactokinase Family
IPR006204 GHMP kinase N-terminal domain GHMP_kinase_N_dom Domain
IPR000705 Galactokinase Galactokinase Family
IPR006205 Mevalonate kinase Mev_gal_kin Family
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup Ribosomal_S5_D2-typ_fold_subgr Domain
IPR000870 Homoserine kinase Homoserine_kinase Family

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Tsay YH Cloning and characterization of ERG8, an essential gene of Saccharomyces cerevisiae that encodes phosphomevalonate kinase. 1991 Mol Cell Biol 11 620-31
Lee M Identification of the gene encoding homoserine kinase from Arabidopsis thaliana and characterization of the recombinant enzyme derived from the gene. 1999 Arch Biochem Biophys 372 135-42
Byres E Crystal structures of Trypanosoma brucei and Staphylococcus aureus mevalonate diphosphate decarboxylase inform on the determinants of specificity and reactivity. 2007 J Mol Biol 371 540-53

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)