InterPro : IPR002204

Name  3-hydroxyisobutyrate dehydrogenase-related, conserved site Short Name  3-OH-isobutyrate_DH-rel_CS
Type  Conserved_site Description  This entry identifies a conserved site in reductases/dehydrogenases.3-hydroxyisobutyrate dehydrogenase () catalyzes the NAD-dependent, reversible oxidation of 3-hydroxbutyrate to methylmalonate []. In eukaryotes, it is a homodimeric mitochondrial protein involved in valine catabolism. In Pseudomonas aeruginosa[](gene mmsB), it is involved in the distal valine metabolic pathway.2-hydroxy-3-oxopropionate reductase () catalyses the NAP(P)H dependent reduction of 2-hydroxy-3-oxopropionate (tartronate semialdehyde) to D-glycerate. 6-phosphogluconate dehydrogenase () catalyzes the NADP-dependent decarboxylation of 6-phosphogluconate to D-ribulose 5-phosphate and CO2.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

5 Found In

Id Name Short Name Type
IPR016040 NAD(P)-binding domain NAD(P)-bd_dom Domain
IPR006115 6-phosphogluconate dehydrogenase, NADP-binding 6PGDH_NADP-bd Domain
IPR011548 3-hydroxyisobutyrate dehydrogenase IsoBut3OH_DH Family
IPR006398 2-hydroxy-3-oxopropionate reductase Tartro_sem_red Family
IPR015815 Hydroxy monocarboxylic acid anion dehydrogenase, HIBADH-type HIBADH-type Family

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages
Rougraff PM Cloning and sequence analysis of a cDNA for 3-hydroxyisobutyrate dehydrogenase. Evidence for its evolutionary relationship to other pyridine nucleotide-dependent dehydrogenases. 1989 J Biol Chem 264 5899-903
Steele MI Characterization of the mmsAB operon of Pseudomonas aeruginosa PAO encoding methylmalonate-semialdehyde dehydrogenase and 3-hydroxyisobutyrate dehydrogenase. 1992 J Biol Chem 267 13585-92

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)