InterPro : IPR018177

Name  L-lactate dehydrogenase, active site Short Name  L-lactate_DH_AS
Type  Active_site Description  NAD-dependent L-lactate dehydrogenases from bacteria and eukaryotes functions as the final step in anaerobic glycolysis. Although lactate dehydrogenases have in some cases been mistaken for malate dehydrogenases due to the similarity of these two substrates and the apparent ease with which evolution can toggle these activities, critical residues have been identified []which can discriminate between the two activities.This entry represents the active site of L-lactate dehydrogenase, and includes a conserved histidine which is essential to the catalytic mechanism.
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Sequence Features

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Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

0 Contains

4 Found In

Id Name Short Name Type
IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal Lactate_DH/Glyco_Ohase_4_C Domain
IPR001557 L-lactate/malate dehydrogenase L-lactate/malate_DH Family
IPR022383 Lactate/malate dehydrogenase, C-terminal Lactate/malate_DH_C Domain
IPR011304 L-lactate dehydrogenase L-lactate_DH Family

0 Parent Features

1 Publications

First Author Title Year Journal Volume Pages
Hannenhalli SS Analysis and prediction of functional sub-types from protein sequence alignments. 2000 J Mol Biol 303 61-76



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)