InterPro : IPR014766

Name  Carboxypeptidase, regulatory domain Short Name  CarboxyPept_regulatory_dom
Type  Domain Description  This domain identifies a number of eukaryotic carboxypeptidases, these include carboxypeptidase D, E (H), N, X, X2 and Z. These are metallopeptidases belong to MEROPS peptidase family M14 (clan MC), subfamily M14B.Carboxypeptidase D (CPD) is a new B-type metallocarboxypeptidase that is membrane bound and has an acidic pH optimum. A hydrophobic region at the N terminus represents the signal peptide, and one near the C terminus that probably represents the transmembrane anchor. A regulatory domain within the protein has been identified as a beta-sandwich, comprising 7 strands in 2 sheets in a greek-key topology. Some family members have an additional 1-2 strands to the common fold [].The bacterial and archaeal sequences having this signature are variously annotated, examples are:Hypothetical/conserved/membrane/cell surface protein N-acetylglucosamine deacetylaseSide tail fibre protein homologue from lambdoid prophage RacHypothetical tonB-linked outer membrane receptorOmpA-related proteinPutative outer membrane protein, probably involved in nutrient bindingTonB-dependent receptorThis entry also includes polysaccharide lyase 4 family members, including rhamnogalacturonate lyase A and B.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

3 Found In

Id Name Short Name Type
IPR015567 Peptidase M14B, caboxypeptidase D Pept_M14B_carboxypept_D2 Family
IPR014501 Uncharacterised conserved protein UCP019317 UCP019317 Family
IPR012103 Peptidase S8A, bacillopeptidase F Pept_S8A_Bpr Family

0 Parent Features

1 Publications

First Author Title Year Journal Volume Pages
Haucke V Dual interaction of synaptotagmin with mu2- and alpha-adaptin facilitates clathrin-coated pit nucleation. 2000 EMBO J 19 6011-9

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)