InterPro : IPR019796

Name  Glucose-6-phosphate dehydrogenase, active site Short Name  G6P_DH_AS
Type  Active_site Description  Glucose-6-phosphate dehydrogenase (G6PD) []catalyses the first step in the pentose pathway, the reduction of glucose-6-phosphate to gluconolactone 6-phosphate. A lysine residue has been identified as a reactive nucleophile associated with the activity of the enzyme []. The sequence around this lysine is totally conserved from bacterial to mammalian G6PD's and is used as the pattern to identify the proteins associated with this entry.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

3 Found In

Id Name Short Name Type
IPR016040 NAD(P)-binding domain NAD(P)-bd_dom Domain
IPR001282 Glucose-6-phosphate dehydrogenase G6P_DH Family
IPR022674 Glucose-6-phosphate dehydrogenase, NAD-binding G6P_DH_NAD-bd Domain

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages
Jeffery J Glucose-6-phosphate dehydrogenase. Structure-function relationships and the Pichia jadinii enzyme structure. 1993 Eur J Biochem 212 41-9
Camardella L Human erythrocyte glucose-6-phosphate dehydrogenase. Identification of a reactive lysyl residue labelled with pyridoxal 5'-phosphate. 1988 Eur J Biochem 171 485-9

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)