InterPro : IPR019796

Name  Glucose-6-phosphate dehydrogenase, active site Short Name  G6P_DH_AS
Type  Active_site Description  Glucose-6-phosphate dehydrogenase (G6PD) []catalyses the first step in the pentose pathway, the reduction of glucose-6-phosphate to gluconolactone 6-phosphate. A lysine residue has been identified as a reactive nucleophile associated with the activity of the enzyme []. The sequence around this lysine is totally conserved from bacterial to mammalian G6PD's and is used as the pattern to identify the proteins associated with this entry.
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

0 Contains

3 Found In

Id Name Short Name Type
IPR016040 NAD(P)-binding domain NAD(P)-bd_dom Domain
IPR001282 Glucose-6-phosphate dehydrogenase G6P_DH Family
IPR022674 Glucose-6-phosphate dehydrogenase, NAD-binding G6P_DH_NAD-bd Domain

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages
Jeffery J Glucose-6-phosphate dehydrogenase. Structure-function relationships and the Pichia jadinii enzyme structure. 1993 Eur J Biochem 212 41-9
Camardella L Human erythrocyte glucose-6-phosphate dehydrogenase. Identification of a reactive lysyl residue labelled with pyridoxal 5'-phosphate. 1988 Eur J Biochem 171 485-9



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)