InterPro : IPR008148

Name  DNA photolyase, class 2 Short Name  DNA_photolyase_2
Type  Family Description  Deoxyribodipyrimidine photolyase (DNA photolyase) []is a DNA repair enzyme. It binds to UV-damaged DNA containing pyrimidine dimers and, upon absorbing a near-UV photon(300 to 500 nm), breaks the cyclobutane ring joining the two pyrimidines of the dimer. DNA photolyase is an enzyme that requires two choromophore-cofactors for its activity: a reduced FADH2 and either 5,10-methenyltetrahydrofolate (5,10-MTFH) or an oxidized 8-hydroxy-5- deazaflavin (8-HDF) derivative (F420). The folate or deazaflavin chromophore appears to function as an antenna, while the FADH2 chromophore is thought to be responsible for electron transfer. On the basis of sequence similarities []DNA photolyases can be grouped into two classes. The second class contains enzymes from Myxococcus xanthus, methanogenic archaebacteria, insects, fish and marsupial mammals. It is not yet known what second cofactor is bound to class 2 enzymes. There are a number of conserved sequence regions in all known class 2 DNA photolyases, especially in the C-terminal part.
 Feedback

Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

3 Contains

Id Name Short Name Type
IPR005101 DNA photolyase, FAD-binding/Cryptochrome, C-terminal Photolyase_FAD-bd/Cryptochr_C Domain
IPR006050 DNA photolyase, N-terminal DNA_photolyase_N Domain
IPR014729 Rossmann-like alpha/beta/alpha sandwich fold Rossmann-like_a/b/a_fold Domain

0 Found In

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages
Jorns MS DNA photorepair: chromophore composition and function in two classes of DNA photolyases. 1990 Biofactors 2 207-11
Yasui A A new class of DNA photolyases present in various organisms including aplacental mammals. 1994 EMBO J 13 6143-51



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)