InterPro : IPR001694

Name  NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H Short Name  NADH_UbQ_OxRdtase_su1/FPO
Type  Family Description  NADH:ubiquinone oxidoreductase (complex I) () is a respiratory-chain enzyme that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane (NADH + ubiquinone = NAD+ + ubiquinol) []. Complex I is a major source of reactive oxygen species (ROS) that are predominantly formed by electron transfer from FMNH(2). Complex I is found in bacteria, cyanobacteria (as a NADH-plastoquinone oxidoreductase), archaea [], mitochondria, and in the hydrogenosome, a mitochondria-derived organelle. In general, the bacterial complex consists of 14 different subunits, while the mitochondrial complex contains homologues to these subunits in addition to approximately 31 additional proteins []. This entry represents subunit 1 NADH:ubiquinone oxidoreductase []. Among the many polypeptide subunits that make up complex I, there are fifteen which are located in the membrane part, seven of which are encoded by the mitochondrial and chloroplast genomes of most species. The most conserved of these organelle-encoded subunits is known as subunit 1 (gene ND1 in mitochondrion, and NDH1 in chloroplast) and seems to contain the ubiquinone binding site.The ND1 subunit is highly similar to subunit 4 of Escherichia coliformate hydrogenlyase (gene hycD), subunit C of hydrogenase-4 (gene hyfC). Paracoccus denitrificansNQO8 and Escherichia colinuoH NADH-ubiquinone oxidoreductase subunits also belong to this family [].This entry also includes the archaeal F420H2 oxidoreductase subunit H (FPO). FPO shuttles electrons from F420H2, via FAD and iron-sulphur (Fe-S) centres, to quinones in the F420H2:heterodisulphide oxidoreduction chain. The immediate electron acceptor for the enzyme in this species is believed to be methanophenazine. Couples the redox reaction to proton translocation (for every two electrons transferred, 0.9 hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

1 Contains

Id Name Short Name Type
IPR018086 NADH:ubiquinone oxidoreductase, subunit 1, conserved site NADH_UbQ_OxRdtase_su1_CS Conserved_site

0 Found In

0 Parent Features

5 Publications

First Author Title Year Journal Volume Pages
Walker JE The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains. 1992 Q Rev Biophys 25 253-324
Friedrich T The respiratory complex I of bacteria, archaea and eukarya and its module common with membrane-bound multisubunit hydrogenases. 2000 FEBS Lett 479 1-5
Schneider D Assembly of the Escherichia coli NADH:ubiquinone oxidoreductase (complex I). 2008 Biochim Biophys Acta 1777 735-9
Weiss H The respiratory-chain NADH dehydrogenase (complex I) of mitochondria. 1991 Eur J Biochem 197 563-76
Weidner U The gene locus of the proton-translocating NADH: ubiquinone oxidoreductase in Escherichia coli. Organization of the 14 genes and relationship between the derived proteins and subunits of mitochondrial complex I. 1993 J Mol Biol 233 109-22

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Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)