InterPro : IPR010097

Name  Malate dehydrogenase, type 1 Short Name  Malate_DH_type1
Type  Family Description  This entry represents the NAD-dependent malate dehydrogenase found in eukaryotes and certain gamma proteobacteria. The enzyme is involved in the citric acid cycle as well as the glyoxalate cycle. Several isoforms exist in eukaryotes. In Saccharomyces cereviseae, for example, there are cytoplasmic, mitochondrial and peroxisomal forms. Although malate dehydrogenases have in some cases been mistaken for lactate dehydrogenases due to the similarity of these two substrates and the apparent ease with which evolution can toggle these activities, critical residues have been identified []which can discriminate between the two activities.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



1 Child Features

Id Name Short Name Type
IPR023958 Malate dehydrogenase, type 1, bacterial Malate_DH_type1_bac Family

5 Contains

Id Name Short Name Type
IPR016040 NAD(P)-binding domain NAD(P)-bd_dom Domain
IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal Lactate_DH/Glyco_Ohase_4_C Domain
IPR001236 Lactate/malate dehydrogenase, N-terminal Lactate/malate_DH_N Domain
IPR022383 Lactate/malate dehydrogenase, C-terminal Lactate/malate_DH_C Domain
IPR001252 Malate dehydrogenase, active site Malate_DH_AS Active_site

0 Found In

1 Parent Features

Id Name Short Name Type
IPR001557 L-lactate/malate dehydrogenase L-lactate/malate_DH Family

1 Publications

First Author Title Year Journal Volume Pages
Hannenhalli SS Analysis and prediction of functional sub-types from protein sequence alignments. 2000 J Mol Biol 303 61-76

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)