InterPro : IPR000465

Name  XPA Short Name  XPA
Type  Family Description  Xeroderma pigmentosum (XP) []is a human autosomal recessive disease,characterised by a high incidence of sunlight-induced skin cancer. Skin cells of individual's with this condition are hypersensitive to ultraviolet light, dueto defects in the incision step of DNA excision repair. There are a minimum ofseven genetic complementation groups involved in this pathway: XP-A to XP-G.XP-A is the most severe form of the disease and is due to defects in a 30 kDanuclear protein called XPA (or XPAC) [].The sequence of the XPA protein is conserved from higher eukaryotes []toyeast (gene RAD14) []. XPA is a hydrophilic protein of 247 to 296 amino-acidresidues which has a C4-type zinc finger motif in its central section.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

4 Contains

Id Name Short Name Type
IPR009061 DNA binding domain, putative DNA-bd_dom_put Domain
IPR022652 Zinc finger, XPA-type, conserved site Znf_XPA_CS Conserved_site
IPR022656 XPA C- terminal XPA_C Domain
IPR022658 XPA, conserved site XPA_CS Conserved_site

0 Found In

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Shimamoto T Molecular cloning of human XPAC gene homologs from chicken, Xenopus laevis and Drosophila melanogaster. 1991 Biochem Biophys Res Commun 181 1231-7
Miura N Identification and characterization of xpac protein, the gene product of the human XPAC (xeroderma pigmentosum group A complementing) gene. 1991 J Biol Chem 266 19786-9
Bankmann M Yeast RAD14 and human xeroderma pigmentosum group A DNA-repair genes encode homologous proteins. 1992 Nature 355 555-8
Tanaka K Xeroderma pigmentosum and nucleotide excision repair of DNA. 1994 Trends Biochem Sci 19 83-6

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)