InterPro : IPR013328

Name  Dehydrogenase, multihelical Short Name  DH_multihelical
Type  Domain Description  This entry represents a multi-helical domain found in several NAD or NADP-utilizing dehydrogenases, including 6-phosphogluconate dehydrogenase [], classes I and II ketol-acid reductoisomerases [], L-3-hydroxyacyl CoA dehydrogenase [], UDP-glucose dehydrogenase [], glycerol-3-phosphate dehydrogenase [], ketopantoate reductase [], N-(1-D-carboxylethyl)-L-norvaline dehydrogenase [], and mannitol 2-dehydrogenase []. This domain is often found in the C-terminal region of the protein.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



8 Child Features

Id Name Short Name Type
IPR006114 6-phosphogluconate dehydrogenase, C-terminal 6PGDH_C Domain
IPR006109 Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal G3P_DH_NAD-dep_C Domain
IPR029154 NADP-dependent 3-hydroxyisobutyrate dehydrogenase, NAD-binding domain NADP-bd Domain
IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal 3HC_DH_C Domain
IPR003421 Opine dehydrogenase Opine_DH Domain
IPR013118 Mannitol dehydrogenase, C-terminal Mannitol_DH_C Domain
IPR013752 Ketopantoate reductase, C-terminal domain KPA_reductase Domain
IPR015814 Phosphogluconate dehydrogenase, NAD-binding, putative, C-terminal Pgluconate_DH_NAD-bd_C Domain

2 Contains

Id Name Short Name Type
IPR006184 6-phosphogluconate-binding site 6PGdom_BS Binding_site
IPR006180 3-hydroxyacyl-CoA dehydrogenase, conserved site 3-OHacyl-CoA_DH_CS Conserved_site

7 Found In

Id Name Short Name Type
IPR011548 3-hydroxyisobutyrate dehydrogenase IsoBut3OH_DH Family
IPR006398 2-hydroxy-3-oxopropionate reductase Tartro_sem_red Family
IPR015815 Hydroxy monocarboxylic acid anion dehydrogenase, HIBADH-type HIBADH-type Family
IPR012799 Fatty oxidation complex, alpha subunit FadB FadB Family
IPR022694 3-hydroxyacyl-CoA dehydrogenase 3-OHacyl-CoA_DH Family
IPR016207 Ketol-acid reductoisomerase, fungi KetolA_reductoisomerase_fun Family
IPR016206 Ketol-acid reductoisomerase KetolA_reductoisomerase Family

1 Parent Features

Id Name Short Name Type
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like 6-PGluconate_DH_C-like Domain

8 Publications

First Author Title Year Journal Volume Pages
Britton KL Crystal structure and active site location of N-(1-D-carboxylethyl)-L-norvaline dehydrogenase. 1998 Nat Struct Biol 5 593-601
Barycki JJ Glutamate 170 of human l-3-hydroxyacyl-CoA dehydrogenase is required for proper orientation of the catalytic histidine and structural integrity of the enzyme. 2001 J Biol Chem 276 36718-26
Li L Importance in catalysis of the 6-phosphate-binding site of 6-phosphogluconate in sheep liver 6-phosphogluconate dehydrogenase. 2006 J Biol Chem 281 25568-76
Tyagi R The crystal structure of a bacterial class II ketol-acid reductoisomerase: domain conservation and evolution. 2005 Protein Sci 14 3089-100
Huh JW Identification of a UDP-glucose-binding site of human UDP-glucose dehydrogenase by photoaffinity labeling and cassette mutagenesis. 2005 Bioconjug Chem 16 710-6
Ou X Crystal structures of human glycerol 3-phosphate dehydrogenase 1 (GPD1). 2006 J Mol Biol 357 858-69
Lobley CM The crystal structure of Escherichia coli ketopantoate reductase with NADP+ bound. 2005 Biochemistry 44 8930-9
Simon-Nobbe B NADP-dependent mannitol dehydrogenase, a major allergen of Cladosporium herbarum. 2006 J Biol Chem 281 16354-60

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)