InterPro : IPR014762

Name  DNA mismatch repair, conserved site Short Name  DNA_mismatch_repair_CS
Type  Conserved_site Description  Mismatch repair contributes to the overall fidelity of DNA replication []. It involves the correction of mismatched base pairs that have been missed by the proofreading element of the DNA polymerase complex. The sequence of some proteins involved in mismatch repair in different organisms have been foundto be evolutionarily related. These proteins include:Escherichia coli and Salmonella typhimurium mutL protein []. MutL is required for dam-dependent methyl-directed DNA repair.Streptococcus pneumoniae hexB protein []. The Hex system is nick directed.Yeast proteins PMS1 and MLH1 [].Human protein MLH1 []which is involved in a form of familial hereditary nonpolyposis colon cancer (HNPCC).This entry represents a perfectly conserved heptapeptide which is located in the N-terminal sectionof these proteins.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

3 Found In

Id Name Short Name Type
IPR003594 Histidine kinase-like ATPase, C-terminal domain HATPase_C Domain
IPR002099 DNA mismatch repair protein family DNA_mismatch_repair_fam Family
IPR020667 DNA mismatch repair protein, MutL DNA_mismatch_repair_MutL Family

0 Parent Features

5 Publications

First Author Title Year Journal Volume Pages
Prudhomme M Nucleotide sequence of the Streptococcus pneumoniae hexB mismatch repair gene: homology of HexB to MutL of Salmonella typhimurium and to PMS1 of Saccharomyces cerevisiae. 1989 J Bacteriol 171 5332-8
Modrich P DNA mismatch correction. 1987 Annu Rev Biochem 56 435-66
Mankovich JA Nucleotide sequence of the Salmonella typhimurium mutL gene required for mismatch repair: homology of MutL to HexB of Streptococcus pneumoniae and to PMS1 of the yeast Saccharomyces cerevisiae. 1989 J Bacteriol 171 5325-31
Prolla TA Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene. 1994 Mol Cell Biol 14 407-15
Bronner CE Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. 1994 Nature 368 258-61

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)