InterPro : IPR002453

Name  Beta tubulin Short Name  Beta_tubulin
Type  Family Description  Microtubules are polymers of tubulin, a dimer of two 55kDa subunits, designated alpha and beta [, ]. Within the microtubule lattice, alpha-betaheterodimers associate in a head-to-tail fashion, giving rise to microtubule polarity. Fluorescent labelling studies have suggested that tubulin isoriented in microtubules with beta-tubulin toward the plus end []. For maximal rate and extent of polymerisation into microtubules, tubulin requires GTP. Two molecules of GTP are bound at different sites, termed N and E. At the E (Exchangeable) site, GTP is hydrolysed during incorporationinto the microtubule. Close to the E site is an invariant region rich in glycine residues, which is found in both chains and is thought to controlaccess of the nucleotide to its binding site []. Most species, excepting simple eukaryotes, express a variety of closely related alpha- and beta-isotypes. A third family member, gamma tubulin, hasalso been identified in a number of species [].British type familial amyloidosis is an autosomal dominant disease characterised by progressive dementia, spastic paralysis and ataxia. Amyloid deposits from the brain tissue of an individual who died with this disease have been characterised. Trypsin digestion and subsequent N-terminalsequence analysis yielded a number of short sequences, all of which aretryptic fragments of the C-termini of human alpha- and beta-tubulin []. Consistent with the definition of amyloid, synthetic peptides based on the sequences of these fragments formed fibrils in vitro, suggesting that theC-termini of both alpha- and beta-tubulin are closely associated with theamyloid deposits of this type of amyloidosis [].This entry represents beta tubulin.
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

4 Contains

Id Name Short Name Type
IPR003008 Tubulin/FtsZ, GTPase domain Tubulin_FtsZ_GTPase Domain
IPR008280 Tubulin/FtsZ, C-terminal Tub_FtsZ_C Domain
IPR018316 Tubulin/FtsZ, 2-layer sandwich domain Tubulin/FtsZ_2-layer-sand-dom Domain
IPR017975 Tubulin, conserved site Tubulin_CS Conserved_site

0 Found In

1 Parent Features

Id Name Short Name Type
IPR000217 Tubulin Tubulin Family

6 Publications

First Author Title Year Journal Volume Pages
Cleveland DW Molecular biology and genetics of tubulin. 1985 Annu Rev Biochem 54 331-65
Joshi HC Gamma-tubulin: the hub of cellular microtubule assemblies. 1993 Bioessays 15 637-43
Joshi HC Diversity among tubulin subunits: toward what functional end? 1990 Cell Motil Cytoskeleton 16 159-63
Hesse J Tubulin sequence region beta 155-174 is involved in binding exchangeable guanosine triphosphate. 1987 J Biol Chem 262 15472-5
Mitchison TJ Localization of an exchangeable GTP binding site at the plus end of microtubules. 1993 Science 261 1044-7
Lewis SA Three expressed sequences within the human beta-tubulin multigene family each define a distinct isotype. 1985 J Mol Biol 182 11-20



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)