InterPro : IPR014721

Name  Ribosomal protein S5 domain 2-type fold, subgroup Short Name  Ribosomal_S5_D2-typ_fold_subgr
Type  Domain Description  Domain 2 of the ribosomal protein S5 has a left-handed beta-alpha-beta fold that is found in numerous RNA/DNA-binding proteins, as well as in kinases from the GHMP kinase family. Proteins containing this beta-alpha-beta fold domain include: Translational machinery components (ribosomal proteins S5 and S9, and domain IV of elongation factors EF-G and eEF-2) [].Ribonuclease P protein (RNase P) [].DNA modification proteins (DNA mismatch repair proteins MutL and PMS2, DNA gyrase B, DNA topoisomerase II, IV-B and VI-B) [].GHMP kinases that transfer a phosphoryl group from ATP to an acceptor (galactokinase (), homoserine kinase (), and mevalonate kinase ()) [, ].Caenorhabditis elegansearly switch protein Xol-1 (a divergent member of the GHMP kinase family that has lost the ATP-binding site) [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



6 Child Features

Id Name Short Name Type
IPR013507 DNA mismatch repair protein, C-terminal DNA_mismatch_repair_C Domain
IPR005324 Ribosomal protein S5, C-terminal Ribosomal_S5_C Domain
IPR005517 Translation elongation factor EFG/EF2, domain IV Transl_elong_EFG/EF2_IV Domain
IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2 Topo_IIA_bsu_dom2 Domain
IPR015192 Switch protein XOL-1, N-terminal Xol-1_N Domain
IPR015320 DNA topoisomerase VI, subunit B, transducer TopoVI_B_transducer Domain

6 Contains

Id Name Short Name Type
IPR006204 GHMP kinase N-terminal domain GHMP_kinase_N_dom Domain
IPR019539 Galactokinase galactose-binding domain GalKase_gal-bd Domain
IPR020574 Ribosomal protein S9, conserved site Ribosomal_S9_CS Conserved_site
IPR019741 Galactokinase, conserved site Galactokinase_CS Conserved_site
IPR006203 GHMP kinase, ATP-binding, conserved site GHMP_knse_ATP-bd_CS Conserved_site
IPR020539 Ribonuclease P, conserved site RNase_P_CS Conserved_site

18 Found In

Id Name Short Name Type
IPR006206 Mevalonate/galactokinase Mevalonate/galactokinase Family
IPR000705 Galactokinase Galactokinase Family
IPR006205 Mevalonate kinase Mev_gal_kin Family
IPR005935 Diphosphomevalonate/phosphomevalonate decarboxylase Mev_decarb Family
IPR002099 DNA mismatch repair protein family DNA_mismatch_repair_fam Family
IPR004540 Translation elongation factor EFG/EF2 Transl_elong_EFG/EF2 Family
IPR004543 Translation elongation factor EFG/EF2, archaeal Transl_elong_EFG/EF2_arc Family
IPR016005 Phosphomevalonate kinase, ERG8 Pmev_kin_ERG8 Family
IPR005916 Phosphomevalonate kinase, eukaryotic Pmev_kin_euk Family
IPR004424 4-diphosphocytidyl-2C-methyl-D-erythritol kinase IspE Family
IPR020667 DNA mismatch repair protein, MutL DNA_mismatch_repair_MutL Family
IPR005734 DNA topoisomerase VI, subunit B TopoVI_B Family
IPR005917 Phosphomevalonate kinase, Gram-positive Pmev_kin_Gpos Family
IPR000870 Homoserine kinase Homoserine_kinase Family
IPR001174 Galactokinase/homoserine kinase Galkinase Family
IPR014606 D,D-heptose 7-phosphate kinase Heptose_7-P_kinase Family
IPR010189 Shikimate kinase, archaea SK_arc Family
IPR012369 Galactokinase, glycosyltransferase Galk_glycosyltransferase Family

1 Parent Features

Id Name Short Name Type
IPR020568 Ribosomal protein S5 domain 2-type fold Ribosomal_S5_D2-typ_fold Domain

6 Publications

First Author Title Year Journal Volume Pages
Ramakrishnan V Structures of prokaryotic ribosomal proteins: implications for RNA binding and evolution. 1995 Biochem Cell Biol 73 979-86
Zhou T Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily. 2000 Structure 8 1247-57
Luz JG XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. 2003 Genes Dev 17 977-90
Guarné A Structure and function of the N-terminal 40 kDa fragment of human PMS2: a monomeric GHL ATPase. 2001 EMBO J 20 5521-31
Marquez SM Structure and function of eukaryotic Ribonuclease P RNA. 2006 Mol Cell 24 445-56
Andreassi JL 2nd Molecular functions of conserved aspects of the GHMP kinase family. 2004 Biochemistry 43 14594-601

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)