InterPro : IPR016160

Name  Aldehyde dehydrogenase, cysteine active site Short Name  Ald_DH_CS_CYS
Type  Conserved_site Description  Aldehyde dehydrogenases (and ) are enzymes that oxidize a wide variety of aliphatic and aromatic aldehydes using NADP as a cofactor. In mammals at least four different forms of the enzyme are known []: class-1 (or Ald C) a tetrameric cytosolic enzyme, class-2 (or Ald M) a tetrameric mitochondrial enzyme, class- 3 (or Ald D) a dimeric cytosolic enzyme, and class IV a microsomal enzyme. Aldehyde dehydrogenases have also been sequenced from fungal and bacterial species. A number of enzymes are known to be evolutionary related to aldehyde dehydrogenases. A glutamic acid and a cysteine residue have been implicated in the catalytic activity of mammalian aldehyde dehydrogenase. These residues are conserved in all the enzymes of this entry. This entry represents the cysteine active site.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

9 Found In

Id Name Short Name Type
IPR015590 Aldehyde dehydrogenase domain Aldehyde_DH_dom Domain
IPR016161 Aldehyde/histidinol dehydrogenase Ald_DH/histidinol_DH Domain
IPR016162 Aldehyde dehydrogenase N-terminal domain Ald_DH_N Domain
IPR011264 NAD/NADP-dependent betaine aldehyde dehydrogenase BADH Family
IPR017649 Succinylglutamic semialdehyde dehydrogenase SuccinylGlu_semiald_DH_AstD Family
IPR011407 10-formyltetrahydrofolate dehydrogenase 10_FTHF_DH Family
IPR011408 Aldehyde dehydrogenase Aldehyde_DH Family
IPR017749 1-pyrroline dehydrogenase 1-pyrroline_dehydrogenase Family
IPR012394 Aldehyde dehydrogenase NAD(P)-dependent Aldehyde_DH_NAD(P) Family

0 Parent Features

1 Publications

First Author Title Year Journal Volume Pages
Hempel J Inducible (class 3) aldehyde dehydrogenase from rat hepatocellular carcinoma and 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated liver: distant relationship to the class 1 and 2 enzymes from mammalian liver cytosol/mitochondria. 1989 Biochemistry 28 1160-7

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)