InterPro : IPR015807

Name  Histidine-tRNA ligase Short Name  His-tRNA-ligase
Type  Family Description  Histidine-tRNA ligase (also known as histidyl-tRNA synthetase) () is an alpha2 dimer that belongs to class IIa. Every completed genome includes a histidine-tRNA ligase. Apparent second copies from Bacillus subtilis, Synechocystis sp.(strain PCC 6803), and Aquifex aeolicusare slightly shorter, more closely related to each other than to other hisS proteins, and not demonstrated to act as histidine-tRNA ligases (see ). Theregulatory protein kinase GCN2 of Saccharomyces cerevisiae(YDR283c), and related proteins from other species designated eIF-2 alpha kinase, have a domain closely related to histidine-tRNA ligase that may serve to detect and respond to uncharged tRNA(his), an indicator of amino acid starvation, but these regulatory proteins are not orthologous.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

3 Contains

Id Name Short Name Type
IPR004154 Anticodon-binding Anticodon-bd Domain
IPR002314 Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain aa-tRNA-synt_IIb_cons-dom Domain
IPR006195 Aminoacyl-tRNA synthetase, class II aa-tRNA-synth_II Domain

0 Found In

1 Parent Features

Id Name Short Name Type
IPR004516 Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit HisRS/HisZ Family

0 Publications

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)