InterPro : IPR006026

Name  Peptidase, metallopeptidase Short Name  Peptidase_Metallo
Type  Domain Description  Metalloproteases are the most diverse of the four main types of protease, with more than 50 families identified to date. In these enzymes, a divalent cation, usually zinc, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. The known metal ligands are His, Glu, Asp or Lys and at least one other residue is required for catalysis, which may play an electrophillic role. Of the known metalloproteases, around half contain an HEXXH motif, which has been shown in crystallographic studies to form part of the metal-binding site []. The HEXXH motif is relatively common, but can be more stringently defined for metalloproteases as 'abXHEbbHbc', where 'a' is most often valine or threonine and forms part of the S1' subsite in thermolysin and neprilysin, 'b' is an uncharged residue, and 'c' a hydrophobic residue. Proline is never found in this site, possibly because it would break the helical structure adopted by this motif in metalloproteases [].The majority of zinc-dependent metallopeptidases (with the notable exceptionof the carboxypeptidases) share a common pattern of primary structure [, ]in the part of their sequence involved in the binding of zinc, and can begrouped together as a superfamily,known as the metzincins, on the basis ofthis sequence similarity. They can be classified into around 40 distinct families []. This signature defines the metallopeptidases associated with MEROPS peptidase families: M7, M8, M10 (subfamilies A, B and C) and M12 (subfamily A) all of which are members of clan MA(M).

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



2 Child Features

Id Name Short Name Type
IPR001506 Peptidase M12A, astacin Peptidase_M12A Domain
IPR001818 Peptidase M10, metallopeptidase Pept_M10_metallopeptidase Domain

0 Contains

12 Found In

Id Name Short Name Type
IPR021190 Peptidase M10A Pept_M10A Family
IPR008294 Meprin alpha/beta subunit Meprin Family
IPR016293 Peptidase M10A, stromelysin-type Pept_M10A_stromelysin-type Family
IPR016294 Peptidase M10B Pept_M10B Family
IPR015446 Bone morphogenetic protein 1/tolloid-like protein BMP_1/tolloid-like Family
IPR017369 SPAN protein/blastula protease 10 SPAN/blastula_protease_10 Family
IPR017050 Metallopeptidase, nematode Metallopeptidase_nem Family
IPR017370 Hatching enzyme, Uvs2 Hatching_enzyme_Uvs2 Family
IPR022603 Domain of unknown function DUF3152 DUF3152 Domain
IPR017367 Peptidase M12A, nematode astacin 7/8 Peptidase_M12A_astacin-7/8 Family
IPR017368 Peptidase M12A, nematode astacin 9/10/11 Peptidase_M12A_astacin-9/10/11 Family
IPR001843 Fragilysin Fragilysin Family

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Rawlings ND Evolutionary families of metallopeptidases. 1995 Methods Enzymol 248 183-228
Jongeneel CV A unique signature identifies a family of zinc-dependent metallopeptidases. 1989 FEBS Lett 242 211-4
Murphy GJ The origin of matrix metalloproteinases and their familial relationships. 1991 FEBS Lett 289 4-7

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)