InterPro : IPR004001

Name  Actin, conserved site Short Name  Actin_CS
Type  Conserved_site Description  Actin [, ]is a ubiquitous protein involved in the formation of filamentsthat are major components of the cytoskeleton. These filaments interact with myosin to produce a sliding effect, which is the basis of muscularcontraction and many aspects of cell motility, including cytokinesis. Eachactin protomer binds one molecule of ATP and has one high affinity site foreither calcium or magnesium ions, as well as several low affinity sites.Actin exists as a monomer in low salt concentrations, but filaments formrapidly as salt concentration rises, with the consequent hydrolysis of ATP.Actin from many sources forms a tight complex with deoxyribonuclease(DNase I) although the significance of this is still unknown. The formationof this complex results in the inhibition of DNase I activity, and actinloses its ability to polymerise. It has been shown that an ATPase domainof actin shares similarity with ATPase domains of hexokinase and hsp70proteins [, ].In vertebrates there are three groups of actin isoforms: alpha, beta and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exists in most cell types as components of the cytoskeleton and as mediators of internal cell motility. In plants there are many isoforms which are probably involved in a variety of functions such as cytoplasmic streaming, cell shape determination, tip growth, graviperception, cell wall deposition, etc.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

1 Found In

Id Name Short Name Type
IPR004000 Actin family Actin Family

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Kabsch W Structure and function of actin. 1992 Annu Rev Biophys Biomol Struct 21 49-76
Herman IM Actin isoforms. 1993 Curr Opin Cell Biol 5 48-55
Flaherty KM Similarity of the three-dimensional structures of actin and the ATPase fragment of a 70-kDa heat shock cognate protein. 1991 Proc Natl Acad Sci U S A 88 5041-5
Bork P An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins. 1992 Proc Natl Acad Sci U S A 89 7290-4

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)