InterPro : IPR011761

Name  ATP-grasp fold Short Name  ATP-grasp
Type  Domain Description  The ATP-grasp superfamily currently includes 17 groups of enzymes, catalyzing ATP-dependent ligation of a carboxylate containing molecule to an amino or thiol group-containing molecule []. They contribute predominantly to macromolecular synthesis. ATP-hydrolysis is used to activate a substrate. For example, DD-ligase transfers phosphate from ATP to D-alanine on the first step of catalysis. On the second step the resulting acylphosphate is attacked by a second D-alanine to produce a DD dipeptide following phosphate elimination [].The ATP-grasp domain contains three conserved motifs, corresponding to the phosphate binding loop and the Mg(2+) binding site []. The fold is characterised by two alpha-beta subdomains that grasp the ATP molecule between them. Each subdomain provides a variable loop that formspart of the active site, with regions from other domains also contributing to the active site, even though these other domains are not conserved between the various ATP-grasp enzymes [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



7 Child Features

Id Name Short Name Type
IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain CbamoylP_synth_lsu-like_ATP-bd Domain
IPR020561 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain PRibGlycinamid_synth_ATP-grasp Domain
IPR013651 ATP-grasp fold, RimK-type ATP-grasp_RimK-type Domain
IPR004218 Prokaryotic glutathione synthetase, ATP-binding GSHS_ATP-bd Domain
IPR003806 ATP-grasp fold, DUF201-type ATP-grasp_DUF201-type Domain
IPR011095 D-alanine--D-alanine ligase, C-terminal Dala_Dala_lig_C Domain
IPR009720 IMP biosynthesis enzyme PurP, C-terminal IMP_biosynth_PurP_C Domain

5 Contains

Id Name Short Name Type
IPR013650 ATP-grasp fold, succinyl-CoA synthetase-type ATP-grasp_succ-CoA_synth-type Domain
IPR013815 ATP-grasp fold, subdomain 1 ATP_grasp_subdomain_1 Domain
IPR020559 Phosphoribosylglycinamide synthetase, conserved site PRibGlycinamide_synth_CS Conserved_site
IPR003135 ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type ATP-grasp_carboxylate-amine Domain
IPR000291 D-alanine--D-alanine ligase/VANA/B/C, conserved site D-Ala_lig_Van_CS Conserved_site

10 Found In

Id Name Short Name Type
IPR005809 Succinyl-CoA synthetase, beta subunit Succ_CoA_synthase_bsu Family
IPR008656 Inositol-tetrakisphosphate 1-kinase Inositol_tetrakis-P_1-kinase Family
IPR000115 Phosphoribosylglycinamide synthetase PRibGlycinamide_synth Family
IPR006284 Glutathione synthetase, prokaryotic Glut_synth_pro Family
IPR011810 Cyanophycin synthetase Cya_phycin_syn Family
IPR016301 Phosphoribosylaminoimidazole carboxylase AIR_COase Family
IPR005875 Phosphoribosylaminoimidazole carboxylase, ATPase subunit AIR_COase_ATPase-su Domain
IPR017534 GNAT-acetyltransferase GNAT-acetyltransferase Family
IPR006335 Glutathione biosynthesis bifunctional protein GshAB Glut_biosynth Family
IPR005862 Phosphoribosylglycinamide formyltransferase 2 PurT Family

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Fan C A common fold for peptide synthetases cleaving ATP to ADP: glutathione synthetase and D-alanine:d-alanine ligase of Escherichia coli. 1995 Proc Natl Acad Sci U S A 92 1172-6
Galperin MY A diverse superfamily of enzymes with ATP-dependent carboxylate-amine/thiol ligase activity. 1997 Protein Sci 6 2639-43
Fan C Vancomycin resistance: structure of D-alanine:D-alanine ligase at 2.3 A resolution. 1994 Science 266 439-43
Murzin AG Structural classification of proteins: new superfamilies. 1996 Curr Opin Struct Biol 6 386-94

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)