InterPro : IPR013020

Name  DNA helicase (DNA repair), Rad3 type Short Name  DNA_helicase_DNA-repair_Rad3
Type  Family Description  Proteins in this family are DNA repair helicases, including Rad3/XPD family and Chl1/DDX11 family members. Rad3/XPD is a component of the TFIIH core complex, which is involved in excision repair of DNA damaged [, ]. DDX11/Chl1 is important for normal cell cycle progression [, ]. Defects in DDX11 are the cause of Warsaw breakage syndrome (WBRS). It is a syndrome characterised by severe microcephaly, pre- and postnatal growth retardation, facial dysmorphism and abnormal skin pigmentation [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



2 Child Features

Id Name Short Name Type
IPR001945 Xeroderma pigmentosum group D protein XPGD_DNA_repair Family
IPR028331 Probable ATP-dependent RNA helicase DDX11/DDX12 DDX11/DDX12 Family

3 Contains

Id Name Short Name Type
IPR010614 DEAD2 DEAD_2 Domain
IPR002464 DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site DNA/RNA_helicase_DEAH_CS Conserved_site
IPR006554 Helicase-like, DEXD box c2 type Helicase-like_DEXD_c2 Domain

0 Found In

0 Parent Features

5 Publications

First Author Title Year Journal Volume Pages
Sung P Reconstitution of TFIIH and requirement of its DNA helicase subunits, Rad3 and Rad25, in the incision step of nucleotide excision repair. 1996 J Biol Chem 271 10821-6
Svejstrup JQ RNA polymerase transcription factor IIH holoenzyme from yeast. 1994 J Biol Chem 269 28044-8
Inoue A Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation. 2007 Cell Cycle 6 1646-54
L Holloway S CHL1 is a nuclear protein with an essential ATP binding site that exhibits a size-dependent effect on chromosome segregation. 2000 Nucleic Acids Res 28 3056-64
van der Lelij P Warsaw breakage syndrome, a cohesinopathy associated with mutations in the XPD helicase family member DDX11/ChlR1. 2010 Am J Hum Genet 86 262-6

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)