InterPro : IPR018039

Name  Intermediate filament protein, conserved site Short Name  Intermediate_filament_CS
Type  Conserved_site Description  Intermediate filaments (IF) []are proteins which are primordial components of the cytoskeleton and the nuclear envelope. They generally form filamentous structures 8 to 14 nm wide. IF proteins are members of a very large multigene family of proteins, which has been subdivided in five major subgroups: Type I: Acidic cytokeratins. Type II: Basic cytokeratins. Type III: Vimentin, desmin, glial fibrillary acidic protein (GFAP), peripherin, and plasticin. Type IV: Neurofilaments L, H and M, alpha-internexin and nestin. Type V: Nuclear lamins A, B1, B2 and C. All IF proteins are structurally similar in that they consist of: a central rod domain comprising some 300 to 350 residues which is arranged in coiled-coiled alpha-helices, with at least two short characteristic interruptions; a N-terminal non-helical domain (head) of variable length; and a C-terminal domain (tail) which is also non-helical, and which shows extreme length variation between different IF proteins. While IF proteins are evolutionary and structurally related, they have limited sequence homologies except in several regions of the rod domain. We use, as a sequence pattern for this class of proteins, a conserved region at the C-terminal extremity of the rod domain. Note:The PROSITE pattern defining this conserved site is:[IV]- {K} - [TACI]- Y - [RKH]- {E} - [LM]- L - [DE].In the third position of the pattern, Ala is found in type IV and V IF proteins, Thr is found in IF proteins of type I, II, III, and VI, Cys in IF from snails, and Ile in IF from worms. In the first position of the pattern Val is found in type VI, Ile is found in all other types.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

3 Found In

Id Name Short Name Type
IPR001664 Intermediate filament protein IF Family
IPR016451 Intermediate filament, ifa/ifb Intermed_filament_ifa/ifb Family
IPR003054 Keratin, type II Keratin_II Family

0 Parent Features

1 Publications

First Author Title Year Journal Volume Pages
Stewart M Intermediate filaments: structure, assembly and molecular interactions. 1990 Curr Opin Cell Biol 2 91-100

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)