InterPro : IPR003954

Name  RNA recognition motif domain, eukaryote Short Name  RRM_dom_euk
Type  Domain Description  Many eukaryotic proteins that are known or supposed to bind single-stranded RNA contain one or more copies of a putative RNA-binding domain of about 90 amino acids. This is known as the eukaryotic putative RNA-binding region RNP-1 signature [, ], or RNA recognition motif (RRM). RRMs are found in a variety of RNA binding proteins, including heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs). The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases []. Two individual SMART models were built which identify subtypes of this domain, and are found exclusively in eukaryotes.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

0 Found In

1 Parent Features

Id Name Short Name Type
IPR000504 RNA recognition motif domain RRM_dom Domain

3 Publications

First Author Title Year Journal Volume Pages
Bandziulis RJ RNA-binding proteins as developmental regulators. 1989 Genes Dev 3 431-7
Birney E Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. 1993 Nucleic Acids Res 21 5803-16
Dreyfuss G Heterogeneous nuclear ribonucleoprotein particles and the pathway of mRNA formation. 1988 Trends Biochem Sci 13 86-91

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)