InterPro : IPR020904

Name  Short-chain dehydrogenase/reductase, conserved site Short Name  Sc_DH/Rdtase_CS
Type  Conserved_site Description  The short-chain dehydrogenases/reductases family (SDR) []is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases. As the first member of this family to be characterised was Drosophila alcohol dehydrogenase, this family used to be called [, , ]'insect-type', or 'short-chain' alcohol dehydrogenases. Most member of this family are proteins of about 250 to 300 amino acid residues. Most dehydrogenases possess at least 2 domains [], the first binding the coenzyme, often NAD, and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis. Little sequence similarity has been found in the coenzyme binding domain although there is a large degree of structural similarity, and it has therefore been suggested that the structure of dehydrogenases has arisen through gene fusion of a common ancestral coenzyme nucleotide sequence with various substrate specific domains [].This entry contains a signature pattern for this family of proteins which covers one of the best conserved regions. It includes two perfectly conserved residues, a tyrosine and a lysine. The tyrosine residue participates in the catalytic mechanism.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

19 Found In

Id Name Short Name Type
IPR016040 NAD(P)-binding domain NAD(P)-bd_dom Domain
IPR002347 Glucose/ribitol dehydrogenase Glc/ribitol_DH Family
IPR002198 Short-chain dehydrogenase/reductase SDR DH_sc/Rdtase_SDR Family
IPR003560 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase DHB_DH Family
IPR017711 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase BphB_TodD Family
IPR002424 Alcohol dehydrogenase, insect-type ADH_insect Family
IPR012115 Bifunctional ribulose 5-phosphate reductase/CDP-ribitol pyrophosphorylase CDP-ribitol_syn Family
IPR002425 Alcohol dehydrogenase, Drosophila-type ADH_Drosophila-type Family
IPR002426 Alcohol dehydrogenase, Ceratitis-type ADH_Ceratitis-type Family
IPR002427 Alcohol dehydrogenase-related ADH-rel Family
IPR015845 Agropine synthesis reductase Mas1 Family
IPR011283 Acetoacetyl-CoA reductase Acetoacetyl-CoA_reductase Family
IPR011284 3-oxoacyl-(acyl-carrier-protein) reductase 3oxo_ACP_reduc Family
IPR011286 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase 2-deoxy-D-gluc_3_DH Family
IPR011294 3-hydroxybutyrate dehydrogenase 3-OHbutyrate_DH Family
IPR011348 17beta-dehydrogenase 17beta_DH Family
IPR014007 Acetoin reductase 23BDH Family
IPR014058 Pteridine reductase Pteridine_reductase Family
IPR017619 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase OH-benzo_CoA_DH_BadH Family

0 Parent Features

5 Publications

First Author Title Year Journal Volume Pages
Jörnvall H Short-chain dehydrogenases/reductases (SDR). 1995 Biochemistry 34 6003-13
Villarroya A The primary structure of alcohol dehydrogenase from Drosophila lebanonensis. Extensive variation within insect 'short-chain' alcohol dehydrogenase lacking zinc. 1989 Eur J Biochem 180 191-7
Persson B Characteristics of short-chain alcohol dehydrogenases and related enzymes. 1991 Eur J Biochem 200 537-43
Neidle E cis-diol dehydrogenases encoded by the TOL pWW0 plasmid xylL gene and the Acinetobacter calcoaceticus chromosomal benD gene are members of the short-chain alcohol dehydrogenase superfamily. 1992 Eur J Biochem 204 113-20
Benyajati C Alcohol dehydrogenase gene of Drosophila melanogaster: relationship of intervening sequences to functional domains in the protein. 1981 Proc Natl Acad Sci U S A 78 2717-21

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)