InterPro : IPR018244

Name  Allergen V5/Tpx-1-related, conserved site Short Name  Allrgn_V5/Tpx1_CS
Type  Conserved_site Description  The cysteine-rich secretory proteins (Crisp) are predominantly found in the mammalian male reproductive tract as well as in the venom of reptiles. This family includes mammalian testis-specific protein (Tpx-1), also known as cysteine-rich secretory protein 2 (CRISP2) []; venom allergen 5 from vespid wasps and venom allergen 3 from fire ants, which are potent allergens that mediate allergic reactions to stings insects of the Hymenoptera family []; plant pathogenesis proteins of the PR-1 family [], which are synthesised during pathogen infection or other stress-related responses; allurin, a sperm chemoattractant [], serotriflin [], etc.The precise function of some of these proteins is still unclear. Tpx-1 or CRISP2 may regulate some ion channels' activity and thereby regulate calcium fluxes during sperm capacitation [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

3 Found In

Id Name Short Name Type
IPR001283 Cysteine-rich secretory protein, allergen V5/Tpx-1-related Allrgn_V5/Tpx1 Family
IPR014044 CAP domain CAP_domain Domain
IPR002413 Ves allergen V5_allergen Family

0 Parent Features

6 Publications

First Author Title Year Journal Volume Pages
Dixon DC Differential targeting of the tobacco PR-1 pathogenesis-related proteins to the extracellular space and vacuoles of crystal idioblasts. 1991 EMBO J 10 1317-24
Kasahara M Cloning and mapping of a testis-specific gene with sequence similarity to a sperm-coating glycoprotein gene. 1989 Genomics 5 527-34
Lu G Sequence analysis and antigenic cross-reactivity of a venom allergen, antigen 5, from hornets, wasps, and yellow jackets. 1993 J Immunol 150 2823-30
Gibbs GM The cysteine-rich secretory protein domain of Tpx-1 is related to ion channel toxins and regulates ryanodine receptor Ca2+ signaling. 2006 J Biol Chem 281 4156-63
Burnett LA Xenopus tropicalis allurin: expression, purification, and characterization of a sperm chemoattractant that exhibits cross-species activity. 2008 Dev Biol 316 408-16
Aoki N Serotriflin, a CRISP family protein with binding affinity for small serum protein-2 in snake serum. 2008 Biochim Biophys Acta 1784 621-8

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)