InterPro : IPR001508

Name  Ionotropic glutamate receptor, metazoa Short Name  Iono_rcpt_met
Type  Family Description  Ionotropic glutamate receptors (iGluRs) are a highly conserved family of ligand-gated ion channels present in animals, plants, and bacteria, which are best characterised for their roles in synaptic communication in vertebrate nervous systems []. A variant subfamily of iGluRs, the Ionotropic Receptors (IRs), consist of non-glutamate-binding chemosensory receptors first identified in Drosophila melanogaster. They function in detecting odors and tastants [].There are three classes of ionotropic glutamate receptors (iGluRs): kainate receptors, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors and N-methyl D-aspartate (NMDA) receptors. The NMDAreceptor is highly permeable to calcium ions and plays a key role in theplasticity of synapses, which is believed to underlie memory and learning,as well as the developmentof the nervous system. Abnormal activation hasbeen suggested to lead to neuronal cell death observed in many acute andchronic disorders such as ischemia, stroke, Alzheimer's disease, andHuntington's disease [].NMDA receptors possess 4 transmembrane (TM) helical domains in the C-terminal half of the sequence and require both glycine and glutamate foractivation, resulting in influx of calcium ions into the cell []. The receptors can also be activated by polyamine, they can be blocked by magnesium ions, inhibited by zinc ions, and modulated by arachidonic acid. Other non-NMDA glutamate receptors (e.g., kainate) are structurally similar to NMDA receptors, but are functionally distinct, possibly as a result of amino acid substitutions at important positions in the sequence.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



1 Child Features

Id Name Short Name Type
IPR030407 Ionotropic receptor 8a-related Ionotropic_rcpt_8a Family

4 Contains

Id Name Short Name Type
IPR001320 Ionotropic glutamate receptor Iontro_rcpt Domain
IPR001828 Extracellular ligand-binding receptor ANF_lig-bd_rcpt Domain
IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain Glu/Gly-bd Domain
IPR001638 Solute-binding protein family 3/N-terminal domain of MltF Solute-binding_3/MltF_N Domain

0 Found In

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Mayer ML Structure and function of glutamate receptor ion channels. 2004 Annu Rev Physiol 66 161-81
Croset V Ancient protostome origin of chemosensory ionotropic glutamate receptors and the evolution of insect taste and olfaction. 2010 PLoS Genet 6 e1001064
Yamazaki M Cloning, expression and modulation of a mouse NMDA receptor subunit. 1992 FEBS Lett 300 39-45

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)