InterPro : IPR022398

Name  Peptidase S8, subtilisin, His-active site Short Name  Peptidase_S8_His-AS
Type  Active_site Description  Subtilases []are an extensive family of serine proteases belonging to the MEROPS peptidase family S8 (subtilisin, clan SB). Members of this family have a catalytic triad in the order Asp, His and Ser in the sequence, which is a different order to that of families S1, S9 and S10. The catalytic activity is provided by a charge relay system similar to that of the trypsin family of serine proteases but which evolved by independent convergent evolution. The sequence around the residues involved in the catalytic triad (Asp, Ser and His) are completely different from that of the analogous residues in the trypsin serine proteases and can be used as signatures specific to that category of proteases. If a protein includes at least two of the three active site signatures, the probability of it being a serine protease from the subtilase family is 100%.This entry represents the conserved sequence around the His active site.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

19 Found In

Id Name Short Name Type
IPR000209 Peptidase S8/S53 domain Peptidase_S8/S53_dom Domain
IPR015500 Peptidase S8, subtilisin-related Peptidase_S8_subtilisin-rel Family
IPR017292 Peptidase S8A, Vpr Peptidase_S8A_Vpr Family
IPR016916 Uncharacterised conserved protein UCP029389, subtilisin-related UCP029389_subtilisin-related Family
IPR012103 Peptidase S8A, bacillopeptidase F Pept_S8A_Bpr Family
IPR008357 Lantibiotic leader peptide-processing serine protease Lanit_process Family
IPR017296 Peptidase S8A, SAM-P45 Peptidase_S8A_SAM-P45 Family
IPR017297 Peptidase S8A, DPH-A Peptidase_S8A_DPH-A Family
IPR017306 Peptidase S8A, fervidolysin Peptidase_S8A_fervidolysin Family
IPR017308 Peptidase S8A, subtilisin-related, bacteroidetes Pept_S8_subtilisin_bacteroid Family
IPR017309 Peptidase S8A, subtilisin-related, proteobacteria Pept_S8A_subtilisin_proteobac Family
IPR017310 Peptidase S8A, subtilisin-related, clostridia Pept_S8A_subtilisin_clostridia Family
IPR017311 Peptidase S8A, subtilisin-related, shewanella Pept_S8A_subtilisin_shewanella Family
IPR017312 Peptidase S8A, subtilisin-related, shewanella-2 Pept_S8A_subtilisin_shewan-2 Family
IPR017314 Peptidase S8A, subtilisin-like peptidase 1, plasmodium Pept_S8A_PfSUB_1 Family
IPR017315 Peptidase S8A, subtilisin-related, proteobacteria-2 Pep_S8A_subtilisin_pbac-2 Family
IPR017316 Peptidase S8A, subtilisin-related, cyanobacteria-2 Pept_S8A_subtilisin_cyanobac-2 Family
IPR017318 Peptidase S8A, subtilisin-related, campylobacter Pept_S8A_subtilisin_campylobac Family
IPR017319 Peptidase S8A, subtilisin-related, prokarya Pept_S8A_subtilisin_pro Family

0 Parent Features

1 Publications

First Author Title Year Journal Volume Pages
Siezen RJ Homology modelling and protein engineering strategy of subtilases, the family of subtilisin-like serine proteinases. 1991 Protein Eng 4 719-37

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)