InterPro : IPR013785

Name  Aldolase-type TIM barrel Short Name  Aldolase_TIM
Type  Domain Description  This entry represents the TIM beta/alpha barrel found in aldolase and in related proteins. This TIM barrel usually covers the entire protein structure. Proteins containing this TIM barrel domain include class I aldolases, class I DAHP synthases, class II fructose-bisphosphate aldolases (FBP aldolases), and 5-aminolaevulinate dehydratase (a hybrid of classes I and II aldolases) [, , ].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



14 Child Features

Id Name Short Name Type
IPR011060 Ribulose-phosphate binding barrel RibuloseP-bd_barrel Domain
IPR002638 Quinolinate phosphoribosyl transferase, C-terminal Quinolinate_PRibosylTrfase_C Domain
IPR000262 FMN-dependent dehydrogenase FMN-dep_DH Domain
IPR000891 Pyruvate carboxyltransferase PYR_CT Domain
IPR006982 Glutamate synthase, central-N Glu_synth_centr_N Domain
IPR002932 Glutamate synthase domain Glu_synthdom Domain
IPR001093 IMP dehydrogenase/GMP reductase IMP_DH_GMPRt Domain
IPR001155 NADH:flavin oxidoreductase/NADH oxidase, N-terminal OxRdtase_FMN_N Domain
IPR022998 Thiamin phosphate synthase superfamily ThiaminP_synth_SF Domain
IPR006218 DAHP synthetase I/KDSA DAHP1/KDSA Domain
IPR013132 N-acetylneuraminic acid synthase, N-terminal Neu5Ac_N Domain
IPR004136 2-nitropropane dioxygenase, NPD 2Npropane_dOase Domain
IPR001381 Dehydroquinase class I DHquinase_I Domain
IPR009215 TIM-barrel domain, IGPS-like TIM-br_IGPS-like Domain

16 Contains

Id Name Short Name Type
IPR008259 FMN-dependent alpha-hydroxy acid dehydrogenase, active site FMN_hydac_DH_AS Active_site
IPR006638 Elongator protein 3/MiaB/NifB Elp3/MiaB/NifB Domain
IPR020861 Triosephosphate isomerase, active site Triosephosphate_isomerase_AS Active_site
IPR000385 MoaA/nifB/pqqE, iron-sulphur binding, conserved site MoaA_NifB_PqqE_Fe-S-bd_CS Conserved_site
IPR001295 Dihydroorotate dehydrogenase, conserved site Dihydroorotate_DH_CS Conserved_site
IPR015875 IMP dehydrogenase / GMP reductase, conserved site IMP_DH/GMP_Rdtase_CS Conserved_site
IPR018517 tRNA-dihydrouridine synthase, conserved site tRNA_hU_synthase_CS Conserved_site
IPR018089 Orotidine 5'-phosphate decarboxylase, active site OMPdecase_AS Active_site
IPR018225 Transaldolase, active site Transaldolase_AS Active_site
IPR020624 Dihydrodipicolinate synthetase, conserved site Dihydrodipicolinate_synth_CS Conserved_site
IPR020625 Dihydrodipicolinate synthetase, active site Dihydrodipicolinate_synth_AS Active_site
IPR002034 Alpha-isopropylmalate/homocitrate synthase, conserved site AIPM/Hcit_synth_CS Conserved_site
IPR018204 Tryptophan synthase, alpha chain, active site Trp_synthase_alpha_AS Active_site
IPR018508 3-dehydroquinate dehydratase, active site 3-dehydroquinate_DH_AS Active_site
IPR001468 Indole-3-glycerol phosphate synthase, conserved site Indole-3-GlycerolPSynthase_CS Conserved_site
IPR000138 Hydroxymethylglutaryl-CoA lyase, active site HMG_CoA_lyase_AS Active_site

48 Found In

Id Name Short Name Type
IPR002241 Glycoside hydrolase, family 27 Glyco_hydro_27 Family
IPR003698 Lipoyl synthase Lipoyl_synth Family
IPR005839 Methylthiotransferase Methylthiotransferase Family
IPR000111 Glycoside hydrolase, clan GH-D Glyco_hydro_GHD Family
IPR013483 Molybdenum cofactor biosynthesis protein A MoaA Family
IPR006466 MiaB-like tRNA modifying enzyme, archaeal-type MiaB-like_B Family
IPR005930 Pyruvate carboxylase Pyruv_COase Family
IPR004393 Nicotinate-nucleotide pyrophosphorylase NadC Family
IPR003733 Thiamine phosphate synthase TMP_synthase Family
IPR012726 Thiazole biosynthesis ThiH ThiH Family
IPR017629 4-hydroxy-2-oxovalerate aldolase 4OH_2_O-val_aldolase Family
IPR005840 Ribosomal protein S12 methylthiotransferase RimO Ribosomal_S12_MeSTrfase_RimO Family
IPR018155 Hyaluronidase Hyaluronidase Family
IPR008289 Pentafunctional AroM protein Pentafunct_AroM Family
IPR004652 tRNA-dihydrouridine synthase, TIM-barrel, NifR3 tRNA_dU_NifR3 Family
IPR006463 tRNA-i(6)A37 modification enzyme MiaB MiaB_methiolase Family
IPR006467 MiaB-like tRNA modifying enzyme MiaB-like_C Family
IPR016779 Radical SAM enzyme, MSMEG0568 rSAM_MSMEG0568 Family
IPR019939 CofG family CofG_family Family
IPR019940 CofH family CofH_family Family
IPR022431 Menaquinone biosynthesis, SCO4550 Menaquinone_biosynth_SCO4550 Family
IPR005911 Conserved hypothetical protein CHP01212 CHP01212 Family
IPR013485 Molybdenum cofactor biosynthesis protein A, archaea MoaA_arc Family
IPR012220 Glutamate synthase, eukaryotic Glu_synth_euk Family
IPR016302 Anthranilate synthase component 2 Anthranilate_synth_II Family
IPR016229 Thiamine-phosphate synthase, cyanobacterial/bacterial TMP_synthase_cyanobac_bac Family
IPR016427 Uncharacterised conserved protein UCP004699, CBS/ParB-like UCP004699_CBS/ParB Family
IPR016426 Uncharacterised conserved protein UCP004698, CBS-type UCP004698_CBS_type Family
IPR016436 Uncharacterised conserved protein UCP005063, CBS-type UCP005063_CBS Family
IPR016486 Uncharacterised conserved protein UCP006591, CBS-type UCP006591_CBS Family

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Erskine PT X-ray structure of 5-aminolaevulinate dehydratase, a hybrid aldolase. 1997 Nat Struct Biol 4 1025-31
Pan H Quaternary structure of aldolase leads to differences in its folding and unfolding intermediates. 2003 Biochemistry 42 5713-21
Heine A Analysis of the class I aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99A resolution. 2004 J Mol Biol 343 1019-34

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)