InterPro : IPR014729

Name  Rossmann-like alpha/beta/alpha sandwich fold Short Name  Rossmann-like_a/b/a_fold
Type  Domain Description  This entry represents domains related by a common ancestor that have a Rossmann-like, 3-layer, alpha/beta/alpha sandwich fold. Protein families in which the domain is found include:Nucleotidylyl transferases () such as cytidylyltransferases [], adenylyltransferases [].Class I aminoacyl-tRNA synthetases (catalytic domain), such as tyrosyl-tRNA synthetase () and glutaminyl-tRNA synthetase () [].Pantothenate synthetases () [].ATP sulphurylase (central domain) []N-type ATP pyrophosphatases, such as beta-lactam synthetase () and GMP synthase () [].PP-loop ATPases such as the cell cycle protein MesJ (N-terminal domain) [].Phosphoadenylyl sulphate (PAPS) reductase []Electron transfer flavoprotein (ETFP) subunits, such as the N-terminal domains of the alpha and beta subunits [].Universal stress protein A (UspA) [].Cryptochrome and DNA photolyase [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



9 Child Features

Id Name Short Name Type
IPR022310 NAD/GMP synthase NAD/GMP_synthase Domain
IPR006016 UspA UspA Domain
IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal ETF_a/b_N Domain
IPR001962 Asparagine synthase Asn_synthase Domain
IPR002500 Phosphoadenosine phosphosulphate reductase PAPS_reduct Domain
IPR024951 Sulphate adenylyltransferase catalytic domain Sulfurylase_cat_dom Domain
IPR011063 tRNA(Ile)-lysidine/2-thiocytidine synthase tRNA-lysidine/thiocyt_synth Domain
IPR003848 Domain of unknown function DUF218 DUF218 Domain
IPR020536 Thil, AANH domain ThiI_AANH Domain

8 Contains

Id Name Short Name Type
IPR004821 Cytidyltransferase-like domain Cyt_trans-like Domain
IPR002300 Aminoacyl-tRNA synthetase, class Ia aa-tRNA-synth_Ia Domain
IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain Val/Leu/Ile-tRNA-synth_edit Domain
IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site aa-tRNA-synth_I_CS Conserved_site
IPR000049 Electron transfer flavoprotein, beta-subunit, conserved site ET-Flavoprotein_bsu_CS Conserved_site
IPR018223 Argininosuccinate synthase, conserved site Arginosuc_synth_CS Conserved_site
IPR020554 Uncharacterised protein family UPF0021, conserved site UPF0021_CS Conserved_site
IPR015864 FAD synthetase FAD_synthase Domain

52 Found In

Id Name Short Name Type
IPR002761 DUF71 domain DUF71_dom Domain
IPR006050 DNA photolyase, N-terminal DNA_photolyase_N Domain
IPR004506 tRNA-specific 2-thiouridylase tRNA-specific_2-thiouridylase Family
IPR002306 Tryptophan-tRNA ligase Trp-tRNA-ligase Family
IPR002305 Aminoacyl-tRNA synthetase, class Ic aa-tRNA-synth_Ic Family
IPR002303 Valine-tRNA ligase Valyl-tRNA_ligase Family
IPR012255 Electron transfer flavoprotein, beta subunit ETF_b Family
IPR001518 Argininosuccinate synthase Arginosuc_synth Family
IPR005248 Probable nicotinate-nucleotide adenylyltransferase NAMN_adtrnsfrase Family
IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain Glu/Gln-tRNA-synth_Ib_cat-dom Domain
IPR001278 Arginine-tRNA ligase Arg-tRNA-ligase Family
IPR001674 GMP synthase, C-terminal GMP_synth_C Domain
IPR002302 Leucine-tRNA ligase Leu-tRNA-ligase Family
IPR006015 Universal stress protein A Universal_stress_UspA Family
IPR002307 Tyrosine-tRNA ligase Tyr-tRNA-ligase Family
IPR000924 Glutamyl/glutaminyl-tRNA synthetase Glu/Gln-tRNA-synth Family
IPR004527 Glutamate-tRNA ligase, bacterial/mitochondrial Glu-tRNA-ligase_bac/mito Family
IPR002301 Isoleucine-tRNA ligase Ile-tRNA-ligase Family
IPR004526 Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic Glu-tRNA-synth_arc/euk Family
IPR006426 Asparagine synthase, glutamine-hydrolyzing Asn_synth_AEB Family
IPR008148 DNA photolyase, class 2 DNA_photolyase_2 Family
IPR004493 Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic Leu-tRNA-synth_Ia_arc/euk Family
IPR015803 Cysteine-tRNA ligase Cys-tRNA-ligase Family
IPR011784 Sulphate adenylyltransferase, small subunit SO4_adenylTrfase_ssu Family
IPR012094 Lysidine-tRNA(Ile) synthetase Lysidine-tRNA-synth Family
IPR018317 Queuosine biosynthesis protein QueC QueC Family
IPR014133 Cryptochrome, DASH Cryptochrome_DASH Family
IPR002081 Cryptochrome/DNA photolyase, class 1 Cryptochrome/DNA_photolyase_1 Family
IPR014134 Cryptochrome, plant Cryptochrome_pln Family
IPR019947 Deoxyribodipyrimidine photo-lyase, 8-HDF type Photolyase_8HDF Family

0 Parent Features

11 Publications

First Author Title Year Journal Volume Pages
Roberts DL Three-dimensional structure of human electron transfer flavoprotein to 2.1-A resolution. 1996 Proc Natl Acad Sci U S A 93 14355-60
Tesmer JJ The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families. 1996 Nat Struct Biol 3 74-86
Savage H Crystal structure of phosphoadenylyl sulphate (PAPS) reductase: a new family of adenine nucleotide alpha hydrolases. 1997 Structure 5 895-906
Fong DH Crystal structure of CTP:glycerol-3-phosphate cytidylyltransferase from Staphylococcus aureus: examination of structural basis for kinetic mechanism. 2006 Biochim Biophys Acta 1764 63-9
Takahashi H Structure and implications for the thermal stability of phosphopantetheine adenylyltransferase from Thermus thermophilus. 2004 Acta Crystallogr D Biol Crystallogr 60 97-104
Nureki O Architectures of class-defining and specific domains of glutamyl-tRNA synthetase. 1995 Science 267 1958-65
Wang S Crystal structure of the pantothenate synthetase from Mycobacterium tuberculosis, snapshots of the enzyme in action. 2006 Biochemistry 45 1554-61
Mougous JD Molecular basis for G protein control of the prokaryotic ATP sulfurylase. 2006 Mol Cell 21 109-22
Nakanishi K Structural basis for lysidine formation by ATP pyrophosphatase accompanied by a lysine-specific loop and a tRNA-recognition domain. 2005 Proc Natl Acad Sci U S A 102 7487-92
Boes N The Pseudomonas aeruginosa universal stress protein PA4352 is essential for surviving anaerobic energy stress. 2006 J Bacteriol 188 6529-38
Huang Y Crystal structure of cryptochrome 3 from Arabidopsis thaliana and its implications for photolyase activity. 2006 Proc Natl Acad Sci U S A 103 17701-6

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)