InterPro : IPR016162

Name  Aldehyde dehydrogenase N-terminal domain Short Name  Ald_DH_N
Type  Domain Description  This entry represents a structural domain found at the N-terminal of aldehyde dehydrogenases []. These proteins contain two similar domains, each with a 3-layer alpha/beta/alpha structure, which probably arose from a duplication; this entry covers the N-terminal a/b/a domain. These enzymes binds NAD differently from other NAD(P)-dependent oxidoreductases. Aldehyde dehydrogenases (and ) are enzymes that oxidize a wide variety of aliphatic and aromatic aldehydes using NADP as a cofactor. In mammals at least four different forms of the enzyme are known []: class-1 (or Ald C) a tetrameric cytosolic enzyme, class-2 (or Ald M) a tetrameric mitochondrial enzyme, class- 3 (or Ald D) a dimeric cytosolic enzyme, and class IV a microsomal enzyme. Aldehyde dehydrogenases have also been sequenced from fungal and bacterial species. A number of enzymes are known to be evolutionary related to aldehyde dehydrogenases. A glutamic acid and a cysteine residue have been implicated in the catalytic activity of mammalian aldehyde dehydrogenase.This domain is also found in gamma-glutamyl phosphate reductases, also known as glutamate-5-semialdehyde dehydrogenases.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

1 Contains

Id Name Short Name Type
IPR016160 Aldehyde dehydrogenase, cysteine active site Ald_DH_CS_CYS Conserved_site

24 Found In

Id Name Short Name Type
IPR015590 Aldehyde dehydrogenase domain Aldehyde_DH_dom Domain
IPR016161 Aldehyde/histidinol dehydrogenase Ald_DH/histidinol_DH Domain
IPR010061 Methylmalonate-semialdehyde dehydrogenase MeMal-semiAld_DH Family
IPR005766 Delta l-pyrroline-5-carboxylate synthetase P5_carboxy_syn Family
IPR000965 Gamma-glutamyl phosphate reductase GPR G-glutamylP_reductase Domain
IPR005931 Delta-1-pyrroline-5-carboxylate dehydrogenase P5CDH/ALDH4A1 Family
IPR012134 Glutamate-5-semialdehyde dehydrogenase Glu-5-SA_DH Family
IPR011264 NAD/NADP-dependent betaine aldehyde dehydrogenase BADH Family
IPR017649 Succinylglutamic semialdehyde dehydrogenase SuccinylGlu_semiald_DH_AstD Family
IPR011407 10-formyltetrahydrofolate dehydrogenase 10_FTHF_DH Family
IPR011408 Aldehyde dehydrogenase Aldehyde_DH Family
IPR017749 1-pyrroline dehydrogenase 1-pyrroline_dehydrogenase Family
IPR012394 Aldehyde dehydrogenase NAD(P)-dependent Aldehyde_DH_NAD(P) Family
IPR011985 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase DH_HpaE Family
IPR017628 2-hydroxymuconic semialdehyde dehydrogenase OHmuconic_semiald_DH Family
IPR010102 Succinate semialdehyde dehydrogenase Succ_semiAld_DH Family
IPR017656 Putative phosphonoacetaldehyde dehydrogenase Put_phosphonoacetaldehyde_DH Family
IPR011966 Phenylacetic acid degradation protein PaaN PaaN-DH Family
IPR005932 Putative 1-pyrroline-5-carboxylate dehydrogenase, Bacillales RocA Family
IPR005933 Delta-1-pyrroline-5-carboxylate dehydrogenase 3 Delta1-pyrroline-5-COlate_DH-3 Domain
IPR012408 Acetaldehyde/propionaldehyde dehydrogenase, EutE/PduP-related Acetald_propionald_DH-rel Family
IPR012079 Bifunctional aldehyde-alcohol dehydrogenase Bifunc_Ald-ADH Family
IPR011975 Phenylacetic acid degradation protein PaaN2 PaaN_2 Family
IPR013357 Acetaldehyde dehydrogenase, acetylating Acetaldehyde_DH_acetylating Family

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages
Hempel J Inducible (class 3) aldehyde dehydrogenase from rat hepatocellular carcinoma and 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated liver: distant relationship to the class 1 and 2 enzymes from mammalian liver cytosol/mitochondria. 1989 Biochemistry 28 1160-7
Perez-Miller SJ Coenzyme isomerization is integral to catalysis in aldehyde dehydrogenase. 2003 Biochemistry 42 7100-9

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)