InterPro : IPR016163

Name  Aldehyde dehydrogenase, C-terminal Short Name  Ald_DH_C
Type  Domain Description  This entry represents a structural domain found at the C-terminal of aldehyde dehydrogenases []. These proteins contain two similar domains, each with a 3-layer alpha/beta/alpha structure, which probably arose from a duplication; this entry covers the C-terminal a/b/a domain. These enzymes bind NAD differently from other NAD(P)-dependent oxidoreductases. Aldehyde dehydrogenases (and ) are enzymes that oxidize a wide variety of aliphatic and aromatic aldehydes using NADP as a cofactor. In mammals at least four different forms of the enzyme are known []: class-1 (or Ald C) a tetrameric cytosolic enzyme, class-2 (or Ald M) a tetrameric mitochondrial enzyme, class- 3 (or Ald D) a dimeric cytosolic enzyme, and class IV a microsomal enzyme. Aldehyde dehydrogenases have also been sequenced from fungal and bacterial species. A number of enzymes are known to be evolutionary related to aldehyde dehydrogenases. A glutamic acid and a cysteine residue have been implicated in the catalytic activity of mammalian aldehyde dehydrogenase.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

1 Contains

Id Name Short Name Type
IPR020593 Gamma-glutamyl phosphate reductase GPR, conserved site G-glutamylP_reductase_CS Conserved_site

5 Found In

Id Name Short Name Type
IPR015590 Aldehyde dehydrogenase domain Aldehyde_DH_dom Domain
IPR016161 Aldehyde/histidinol dehydrogenase Ald_DH/histidinol_DH Domain
IPR005766 Delta l-pyrroline-5-carboxylate synthetase P5_carboxy_syn Family
IPR000965 Gamma-glutamyl phosphate reductase GPR G-glutamylP_reductase Domain
IPR012134 Glutamate-5-semialdehyde dehydrogenase Glu-5-SA_DH Family

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages
Hempel J Inducible (class 3) aldehyde dehydrogenase from rat hepatocellular carcinoma and 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated liver: distant relationship to the class 1 and 2 enzymes from mammalian liver cytosol/mitochondria. 1989 Biochemistry 28 1160-7
Perez-Miller SJ Coenzyme isomerization is integral to catalysis in aldehyde dehydrogenase. 2003 Biochemistry 42 7100-9

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)