InterPro : IPR029006

Name  ADF-H/Gelsolin-like domain Short Name  ADF-H/Gelsolin-like_dom
Type  Domain Description  This entry represents a domain found in the actin-depolymerising factors (ADF), the villin/gelsolin family members and the C-terminal of the Sec23/Sec24 proteins. It consists the mixed beta-sheet structure. The ADF-H (actin-depolymerising factor homology) domain is an ~150-amino acid motif that is present in three phylogenetically distinct classes of eukaryotic actin-binding proteins [, , ]. This domain share structural similarity with another set of actin binding proteins, villin and gelsolin, and the C-terminal of the Sec23/Sec24 proteins.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



2 Child Features

Id Name Short Name Type
IPR007123 Gelsolin-like domain Gelsolin-like_dom Domain
IPR002108 Actin-depolymerising factor homology domain ADF-H Domain

0 Contains

0 Found In

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Paavilainen VO Structural conservation between the actin monomer-binding sites of twinfilin and actin-depolymerizing factor (ADF)/cofilin. 2002 J Biol Chem 277 43089-95
Lappalainen P The ADF homology (ADF-H) domain: a highly exploited actin-binding module. 1998 Mol Biol Cell 9 1951-9
Liu LX Structure and expression of a novel filarial gene for glia maturation factor. 1997 Gene 186 1-5

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)