InterPro : IPR013838

Name  Beta tubulin, autoregulation binding site Short Name  Beta-tubulin_BS
Type  Binding_site Description  The stability of beta-tubulin mRNAs are autoregulated by their own translation product []. Unpolymerised tubulin subunits bind directly (or activate a factor(s) which binds co-translationally) to the nascent N terminus of beta-tubulin. This binding is transduced through the adjacent ribosomes to activate an RNAse that degrades the polysome-bound mRNA. The recognition element has been shown to be the first four amino acids of beta-tubulin: Met-Arg-Glu-Ile. Mutations to this sequence abolish the autoregulation effect (except for the replacement of Glu by Asp); transposition of this sequence to an internal region of a polypeptide also suppresses the autoregulatory effect.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

1 Found In

Id Name Short Name Type
IPR003008 Tubulin/FtsZ, GTPase domain Tubulin_FtsZ_GTPase Domain

0 Parent Features

1 Publications

First Author Title Year Journal Volume Pages
Cleveland DW Autoregulated instability of tubulin mRNAs: a novel eukaryotic regulatory mechanism. 1988 Trends Biochem Sci 13 339-43

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)