InterPro : IPR002452

Name  Alpha tubulin Short Name  Alpha_tubulin
Type  Family Description  Microtubules are polymers of tubulin, a dimer of two 55kDa subunits, designated alpha and beta [, ]. Within the microtubule lattice, alpha-betaheterodimers associate in a head-to-tail fashion, giving rise to microtubule polarity. Fluorescent labelling studies have suggested that tubulin isoriented in microtubules with beta-tubulin toward the plus end []. For maximal rate and extent of polymerisation into microtubules, tubulin requires GTP. Two molecules of GTP are bound at different sites, termed N and E. At the E (Exchangeable) site, GTP is hydrolysed during incorporationinto the microtubule. Close to the E site is an invariant region rich in glycine residues, which is found in both chains and is thought to controlaccess of the nucleotide to its binding site []. Most species, excepting simple eukaryotes, express a variety of closely related alpha- and beta-isotypes. A third family member, gamma tubulin, hasalso been identified in a number of species [].This entry represents alpha tubulin.
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

4 Contains

Id Name Short Name Type
IPR003008 Tubulin/FtsZ, GTPase domain Tubulin_FtsZ_GTPase Domain
IPR008280 Tubulin/FtsZ, C-terminal Tub_FtsZ_C Domain
IPR018316 Tubulin/FtsZ, 2-layer sandwich domain Tubulin/FtsZ_2-layer-sand-dom Domain
IPR017975 Tubulin, conserved site Tubulin_CS Conserved_site

0 Found In

1 Parent Features

Id Name Short Name Type
IPR000217 Tubulin Tubulin Family

5 Publications

First Author Title Year Journal Volume Pages
Cleveland DW Molecular biology and genetics of tubulin. 1985 Annu Rev Biochem 54 331-65
Joshi HC Gamma-tubulin: the hub of cellular microtubule assemblies. 1993 Bioessays 15 637-43
Joshi HC Diversity among tubulin subunits: toward what functional end? 1990 Cell Motil Cytoskeleton 16 159-63
Hesse J Tubulin sequence region beta 155-174 is involved in binding exchangeable guanosine triphosphate. 1987 J Biol Chem 262 15472-5
Mitchison TJ Localization of an exchangeable GTP binding site at the plus end of microtubules. 1993 Science 261 1044-7



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)