InterPro : IPR018122

Name  Transcription factor, fork head, conserved site Short Name  TF_fork_head_CS
Type  Conserved_site Description  The fork head protein of Drosophila melanogaster, a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors []. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiaeHCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [, , ].The fork head domain binds B-DNA as a monomer [], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

2 Found In

Id Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain
IPR001766 Transcription factor, fork head TF_fork_head Domain

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Weigel D The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo. 1989 Cell 57 645-58
Clark KL Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. 1993 Nature 364 412-20
Häcker U Developmentally regulated Drosophila gene family encoding the fork head domain. 1992 Proc Natl Acad Sci U S A 89 8754-8

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)