InterPro : IPR000152

Name  EGF-type aspartate/asparagine hydroxylation site Short Name  EGF-type_Asp/Asn_hydroxyl_site
Type  PTM Description  Post-translational hydroxylation of aspartic acid or asparagine []to formerythro-beta-hydroxyaspartic acid or erythro-beta-hydroxyasparagine has beenidentified in a number of proteins with domains homologous to epidermal growthfactor (EGF). Examples of such proteins are the blood coagulation proteinfactors VII, IX and X, proteins C, S, and Z, the LDL receptor, thrombomodulin,etc. Based on sequence comparisons of the EGF-homology region that containshydroxylated Asp or Asn, a consensus sequence has been identified that seemsto be required by the hydroxylase(s).

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

10 Found In

Id Name Short Name Type
IPR001881 EGF-like calcium-binding domain EGF-like_Ca-bd_dom Domain
IPR000742 Epidermal growth factor-like domain EG-like_dom Domain
IPR011398 Fibrillin/Microneme protein4 FBN/EtMIC4 Family
IPR016317 Pro-epidermal growth factor Pro-epidermal_GF Family
IPR016316 Complement component C1q/Thrombomodulin CD93/CD141 Family
IPR008297 Notch Notch Family
IPR003056 GPCR, family 2, CD97 antigen GPCR_2_CD97 Family
IPR015446 Bone morphogenetic protein 1/tolloid-like protein BMP_1/tolloid-like Family
IPR017048 Fibulin-1 Fibulin-1 Family
IPR001491 Thrombomodulin Thrombomodulin Family

0 Parent Features

1 Publications

First Author Title Year Journal Volume Pages
Stenflo J beta-Hydroxyaspartic acid or beta-hydroxyasparagine in bovine low density lipoprotein receptor and in bovine thrombomodulin. 1988 J Biol Chem 263 21-4

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)