InterPro : IPR000629

Name  ATP-dependent RNA helicase DEAD-box, conserved site Short Name  RNA-helicase_DEAD-box_CS
Type  Conserved_site Description  A number of eukaryotic and prokaryotic proteins involved in ATP-dependent, nucleic-acid unwinding have been characterised [, , ]on the basis of their structural similarity. All these proteins share a number of conserved sequence motifs. Some of them are specific to this family while others are shared by other ATP-binding proteins or by proteins belonging to the helicases `superfamily'. One of these motifs, called the 'D-E-A-D-box', represents a special version of the B motif of ATP-binding proteins. Proteins currently known to belong to this family include eukaryotic initiation factor eIF-4A; yeast PRP5, PRP28 and MSS116 splicing proteins, and proteins DHH1, DRS1, MAK5 and ROK1; mouse Pl10, Caenorhabditis eleganshelicase glh-1; Drosophila Rm62 (p62), Me31B and Vasa; and Escherichia coliputative RNA helicases dbpA, deaD, rhlB and rhlE.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

2 Found In

Id Name Short Name Type
IPR011545 DEAD/DEAH box helicase domain DEAD/DEAH_box_helicase_dom Domain
IPR014001 Helicase superfamily 1/2, ATP-binding domain Helicase_ATP-bd Domain

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Schmid SR D-E-A-D protein family of putative RNA helicases. 1992 Mol Microbiol 6 283-91
Linder P Birth of the D-E-A-D box. 1989 Nature 337 121-2
Wassarman DA RNA splicing. Alive with DEAD proteins. 1991 Nature 349 463-4

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)