InterPro : IPR002464

Name  DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site Short Name  DNA/RNA_helicase_DEAH_CS
Type  Conserved_site Description  A number of eukaryotic and prokaryotic proteins have been characterised [, , ]on the basis of their structural similarity. They all seem to be involvedin ATP-dependent, nucleic-acid unwinding. There are two subfamilies of such proteins, the D-E-A-D-box and D-E-A-H-box families.Proteins that belong to the subfamily which have His instead of the secondAsp are said to be 'D-E-A-H-box' proteins [, , ]. Proteins currently known to belong to this subfamily includeyeast PRP2, PRP16, PRP22 and PRP43, involved invarious ATP-requiring steps of the pre-mRNA splicing process; fission yeast prh1, which my be involved in pre-mRNA splicing; Drosophila male-less (mle) protein required in males for dosage compensation of X chromosome linked genes; yeast RAD3, a DNA helicase involved in excision repair of DNAdamaged by UV light, bulky adducts or cross-linking agents; fission yeast rad15 (rhp3) and mammalian DNA excision repair protein XPD (ERCC-2);yeast CHL1 (or CTF1), which is important for chromosome transmission andnormal cell cycle progression in G(2)/M; yeast TPS1, Caenorhabditis eleganshypothetical proteins C06E1.10 and K03H1.2; Poxviruses' early transcription factor 70kDa subunit which acts with RNA polymerase to initiate transcription from early gene promoters; Vaccinia virusputative helicase I8; and Escherichia coliputative RNA helicase hrpA.All these proteins share a number of conserved sequence motifs. Some of themare specific to this family while others are shared by other ATP-bindingproteins or by proteins belonging to the helicases `superfamily' [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

4 Found In

Id Name Short Name Type
IPR014001 Helicase superfamily 1/2, ATP-binding domain Helicase_ATP-bd Domain
IPR013020 DNA helicase (DNA repair), Rad3 type DNA_helicase_DNA-repair_Rad3 Family
IPR006554 Helicase-like, DEXD box c2 type Helicase-like_DEXD_c2 Domain
IPR001945 Xeroderma pigmentosum group D protein XPGD_DNA_repair Family

0 Parent Features

6 Publications

First Author Title Year Journal Volume Pages
Schmid SR D-E-A-D protein family of putative RNA helicases. 1992 Mol Microbiol 6 283-91
Linder P Birth of the D-E-A-D box. 1989 Nature 337 121-2
Wassarman DA RNA splicing. Alive with DEAD proteins. 1991 Nature 349 463-4
Harosh I The RAD3 gene is a member of the DEAH family RNA helicase-like protein. 1991 Nucleic Acids Res 19 6331
Koonin EV Vaccinia virus encodes four putative DNA and/or RNA helicases distantly related to each other. 1992 J Gen Virol 73 ( Pt 4) 989-93
Hodgman TC A new superfamily of replicative proteins. 1988 Nature 333 22-3

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)