InterPro : IPR011042

Name  Six-bladed beta-propeller, TolB-like Short Name  6-blade_b-propeller_TolB-like
Type  Domain Description  This entry represents a six-bladed beta-propeller domain consisting of six 4-stranded beta-sheet motifs. This domain can be found in TolB proteins (C-terminal), in soluble quinoprotein glucose dehydrogenase, in calcium-dependent phosphotriesterases, in the low density lipoprotein (LDL) receptor YWTD domain, in nidogen, and in serine/threonine-protein kinase (PknD) NHL repeat domain.TolB is a periplasmic protein from Escherichia colithat is part of the Tol-dependent translocation system involving group A and E colicins that is used to penetrate and kill cells [, ]. TolB has two domains, an alpha-helical N-terminal domain () that shares structural similarity with the C-terminal domain of transfer RNA ligases, and a beta-propeller C-terminal domain that shares structural similarity with numerous members of the prolyl oligopeptidase family and, to a lesser extent, to class B metallo-beta-lactamases (although its does not necessarily occur at the C-terminal in these proteins) []. The C-terminal domain of TolB may mediate protein-protein interactions with colicins.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



2 Child Features

Id Name Short Name Type
IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase Quinoprot_gluc/sorb_DH Domain
IPR013658 SMP-30/Gluconolactonase/LRE-like region SGL Domain

6 Contains

Id Name Short Name Type
IPR001258 NHL repeat NHL_repeat Repeat
IPR011659 WD40-like Beta Propeller PD40 Repeat
IPR018119 Strictosidine synthase, conserved region Strictosidine_synth_cons-reg Domain
IPR000033 LDLR class B repeat LDLR_classB_rpt Repeat
IPR013017 NHL repeat, subgroup NHL_repeat_subgr Repeat
IPR012938 Glucose/Sorbosone dehydrogenase Glc/Sorbosone_DH Domain

9 Found In

Id Name Short Name Type
IPR004141 Strictosidine synthase Strictosidine_synthase Family
IPR000720 Peptidyl-glycine alpha-amidating monooxygenase Pep_amidat_mOase Family
IPR014167 Tol-Pal system beta propeller repeat-containing protein, TolB Tol-Pal_propeller_TolB Family
IPR002640 Arylesterase Arylesterase Family
IPR016317 Pro-epidermal growth factor Pro-epidermal_GF Family
IPR017049 Low density lipoprotein receptor-related protein, 5/6 Low_density_Lipo_rcpt-rel_p5/6 Family
IPR008363 Paraoxonase1 Paraoxonase1 Family
IPR008364 Paraoxonase2 Paraoxonase2 Family
IPR017549 Acanthamoeba polyphaga mimivirus, L690 APMV_L690 Domain

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages
Abergel C Structure of the Escherichia coli TolB protein determined by MAD methods at 1.95 A resolution. 1999 Structure 7 1291-300
Carr S The structure of TolB, an essential component of the tol-dependent translocation system, and its protein-protein interaction with the translocation domain of colicin E9. 2000 Structure 8 57-66

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)