InterPro : IPR019763

Name  Dynein light chain, type 1/2, conserved site Short Name  Dynein_light_1/2_CS
Type  Conserved_site Description  Dynein is a multisubunit microtubule-dependent motor enzyme that acts as the force generating protein of eukaryotic cilia and flagella. The cytoplasmic isoform of dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein is composed of a number of ATP-binding large subunits (see ), intermediate size subunits and small subunits. Among the small subunits, there is a family of highly conserved proteins which make up this family [, ].Both type 1 (DLC1) and 2 (DLC2) dynein light chains have a similar two-layer alpha-beta core structure consisting of beta-alpha(2)-beta-X-beta(2) [, ].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

1 Found In

Id Name Short Name Type
IPR001372 Dynein light chain, type 1/2 Dynein_light_chain_typ-1/2 Family

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
King SM The M(r) = 8,000 and 11,000 outer arm dynein light chains from Chlamydomonas flagella have cytoplasmic homologues. 1995 J Biol Chem 270 11445-52
Dick T Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster. 1996 Mol Cell Biol 16 1966-77
Liang J Structure of the PIN/LC8 dimer with a bound peptide. 1999 Nat Struct Biol 6 735-40
Day CL Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands. 2004 Biochem J 377 597-605

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)