InterPro : IPR018247

Name  EF-Hand 1, calcium-binding site Short Name  EF_Hand_1_Ca_BS
Type  Binding_site Description  Many calcium-binding proteins belong to the same evolutionary family and sharea type of calcium-binding domain known as the EF-hand. This type ofdomain consists of a twelve residue loop flanked on both sides by a twelveresidue alpha-helical domain. In an EF-hand loop the calcium ion iscoordinated in a pentagonal bipyramidal configuration. The six residuesinvolved in the binding are in positions 1, 3, 5, 7, 9 and 12; these residuesare denoted by X, Y, Z, -Y, -X and -Z. The invariant Glu or Asp at position 12provides two oxygens for liganding Ca (bidentate ligand).This signature pattern includes the complete EF-hand loop as well as the first residue which follows the loop and which seem to always be hydrophobic. Note: positions 1 (X), 3 (Y) and 12 (-Z) are the most conserved. The 6th residue in an EF-hand loop is, in most cases a Gly, but the number of exceptions to this 'rule' has gradually increased, therefore, this signature pattern includes all the different residues which have been shown to exist in this position in functional Ca-binding sites. The pattern is known, in some cases, to miss one of the EF-hand regions in some proteins with multiple EF-hand domains.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

18 Found In

Id Name Short Name Type
IPR011992 EF-hand domain pair EF-hand-dom_pair Domain
IPR000261 EPS15 homology (EH) EPS15_homology Domain
IPR019577 SPARC/Testican, calcium-binding domain SPARC/Testican_Ca-bd-dom Domain
IPR001751 S100/Calbindin-D9k, conserved site S100/CaBP-9k_CS Conserved_site
IPR016134 Cellulosome enzyme, dockerin type I Cellulos_enz_dockerin_1 Domain
IPR002105 Cellulosome enzyme, dockerin type I, calcium-binding motif Cellulos_enz_dockerin_1_Ca-bd Repeat
IPR016688 Mechanosensitive ion channel MscS-like, plants/fungi MscS-like_plants/fungi Family
IPR016359 SPARC-like protein 1 SPARC-like_p1 Family
IPR016279 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma PLC-gamma Family
IPR003299 Flagellar calcium-binding protein calflagin Calflagin-bd Family
IPR008080 Parvalbumin Parvalbumin Family
IPR015754 Calcium binding protein 2 Ca-bd_2 Family
IPR015756 Guanylate cyclase activating protein 2 GCAP-2 Family
IPR012008 Serine/threonine protein phosphatase, EF-hand-containing Ser/Thr-Pase_EF-hand_contain Family
IPR015757 Calcineurin B protein Calcineur_B Family
IPR021181 Small GTPase superfamily, mitochondrial Rho Rho_GTPase_Mt Family
IPR009208 Mosquitocidal toxin Mtx2_tox Family
IPR012045 Peptidase M6, unassigned InhA-related Pept_M6_InhA-rel Family

0 Parent Features

0 Publications

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)