InterPro : IPR000449

Name  Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal Short Name  UBA/Ts_N
Type  Domain Description  UBA domains are a commonly occurring sequence motif of approximately 45 amino acid residues that are found in diverse proteins involved in the ubiquitin/proteasome pathway, DNA excision-repair, and cell signalling via protein kinases []. The human homologue of yeast Rad23A is one example of a nucleotide excision-repair protein that contains both an internal and a C-terminal UBA domain. The solution structure of human Rad23A UBA(2) showed that the domain forms a compact three-helix bundle []. Comparison of the structures of UBA(1) and UBA(2) reveals that both form very similar folds and have a conserved large hydrophobic surface patch which may be a common protein-interacting surface present in diverse UBA domains. Evidence that ubiquitin binds to UBA domains leads to the prediction that the hydrophobic surface patch of UBA domains interacts with the hydrophobic surface on the five-stranded beta-sheet of ubiquitin [].This domain is similar in sequence to the N-terminal domain of translation elongation factor EF1B (or EF-Ts) from bacteria, mitochondria and chloroplasts [].
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

1 Child Features

Id Name Short Name Type
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote UBA/transl_elong_EF1B_N_euk Domain

1 Contains

Id Name Short Name Type
IPR018101 Translation elongation factor Ts, conserved site Transl_elong_Ts_CS Conserved_site

7 Found In

Id Name Short Name Type
IPR009060 UBA-like UBA-like Domain
IPR016641 Nascent polypeptide-associated complex subunit alpha EGD2/NACA Family
IPR001816 Translation elongation factor EFTs/EF1B Transl_elong_EFTs/EF1B Family
IPR015496 Ubiquilin Ubiquilin Family
IPR004806 UV excision repair protein Rad23 Rad23 Family
IPR016652 Ubiquitinyl hydrolase Ubiquitinyl_hydrolase Family
IPR005231 Nascent polypeptide-associated complex (NAC), archaeal NAC_arc Family

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Dieckmann T Structure of a human DNA repair protein UBA domain that interacts with HIV-1 Vpr. 1998 Nat Struct Biol 5 1042-7
Hofmann K The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway. 1996 Trends Biochem Sci 21 172-3
Kawashima T The structure of the Escherichia coli EF-Tu.EF-Ts complex at 2.5 A resolution. 1996 Nature 379 511-8
Mueller TD Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions. 2002 J Mol Biol 319 1243-55



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)