InterPro : IPR011989

Name  Armadillo-like helical Short Name  ARM-like
Type  Domain Description  This domain consists of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed superhelix, where the repeats that make up this structure are arranged about a common axis []. These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. This topology has been found with a number of repeats and domains, including the armadillo repeat (found in beta-catenins and importins), the HEAT repeat (found in protein phosphatase 2a and initiation factor eIF4G), the PHAT domain (found in Smaug RNA-binding protein), the leucine-rich repeat variant, the Pumilo repeat, and in the H regulatory subunit of V-type ATPases. The sequence similarity among these different repeats or domains is low, however they exhibit considerable structural similarity. Furthermore, the number of repeats present in the superhelical structure can vary between orthologues, indicating that rapid loss/gain of repeats has occurred frequently in evolution. A common phylogenetic origin has been proposed for the armadillo and HEAT repeats [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



1 Child Features

Id Name Short Name Type
IPR024574 Domain of unknown function DUF3361 DUF3361 Domain

16 Contains

Id Name Short Name Type
IPR002015 Proteasome/cyclosome repeat Proteasome/cyclosome_rpt Repeat
IPR013598 Exportin-1/Importin-beta-like Exportin-1/Importin-b-like Domain
IPR013918 Nucleotide exchange factor Fes1 Nucleotide_exch_fac_Fes1 Domain
IPR001313 Pumilio RNA-binding repeat Pumilio_RNA-bd_rpt Repeat
IPR000225 Armadillo Armadillo Repeat
IPR001494 Importin-beta, N-terminal domain Importin-beta_N Domain
IPR000357 HEAT HEAT Repeat
IPR014877 CRM1 C-terminal domain CRM1_C_dom Domain
IPR013932 TATA-binding protein interacting (TIP20) TATA-bd_TIP120 Domain
IPR005043 CAS/CSE, C-terminal CAS_CSE1_C Domain
IPR013713 Exportin/Importin, Cse1-like Cse1 Domain
IPR004155 PBS lyase HEAT-like repeat PBS_lyase_HEAT Repeat
IPR021133 HEAT, type 2 HEAT_type_2 Repeat
IPR007205 Protein HGH1 N-terminal Protein_HGH1_N Domain
IPR007206 Protein HGH1 C-terminal Protein_HGH1_C Domain
IPR004830 Leucine rich repeat variant LRR_variant Repeat

16 Found In

Id Name Short Name Type
IPR004908 ATPase, V1 complex, subunit H ATPase_V1-cplx_hsu Family
IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal Clathrin/coatomer_adapt-like_N Domain
IPR016460 Coatomer beta subunit (COPB1) COPB1 Family
IPR008658 Kinesin-associated protein 3 KAP3 Family
IPR017106 Coatomer gamma subunit Coatomer_gsu Family
IPR013284 Beta-catenin Beta-catenin Family
IPR017107 Adaptor protein complex AP-1, gamma subunit AP1_complex_gsu Family
IPR006911 Armadillo repeat-containing domain ARM-rpt_dom Domain
IPR017109 Adaptor protein complex AP-4, epsilon subunit AP4_complex_esu Family
IPR016342 AP-1, 2,4 complex subunit beta AP_complex_bsu_1_2_4 Family
IPR016642 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit 26S_Psome_Rpn2 Family
IPR017104 Adaptor protein complex AP-2, alpha subunit AP2_complex_asu Family
IPR017105 Adaptor protein complex AP-3, delta subunit AP3_complex_dsu Family
IPR007673 Condensin subunit 1 Condensin_cplx_su1 Family
IPR011959 Conserved hypothetical protein CHP02270 CHP02270 Family
IPR008665 LRV FeS4 cluster LRV_FeS Domain

1 Parent Features

Id Name Short Name Type
IPR016024 Armadillo-type fold ARM-type_fold Domain

2 Publications

First Author Title Year Journal Volume Pages
Groves MR Topological characteristics of helical repeat proteins. 1999 Curr Opin Struct Biol 9 383-9
Andrade MA Protein repeats: structures, functions, and evolution. 2001 J Struct Biol 134 117-31

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)