InterPro : IPR015149

Name  Thrombomodulin-like, EGF-like Short Name  Tme5_EGF-like
Type  Domain Description  This domain adopts a fold similar to other EGF domains, with a flat major and a twisted minor beta sheet. Disulphide pairing, however, is not of the usual 1-3, 2-4, 5-6 type; rather 1-2, 3-4, 5-6 pairing is found. Its extended major sheet (strands beta-2 and beta-3 and the connecting loop) projects into thrombin's active site groove. This domain is required for interaction of thrombomodulin with thrombin, and subsequent activation of protein-C [].
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

1 Contains

Id Name Short Name Type
IPR013032 EGF-like, conserved site EGF-like_CS Conserved_site

2 Found In

Id Name Short Name Type
IPR016316 Complement component C1q/Thrombomodulin CD93/CD141 Family
IPR001491 Thrombomodulin Thrombomodulin Family

0 Parent Features

1 Publications

First Author Title Year Journal Volume Pages
Fuentes-Prior P Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex. 2000 Nature 404 518-25



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)