InterPro : IPR030004

Name  Gelsolin Short Name  Gelsolin
Type  Family Description  Gelsolin is an actin-modulating protein that severs F-actin, caps the barbed ends of actin filaments preventing monomer exchange, and promotes the nucleation step of actin polymerisation [, ]. It can be regulated by Ca2+ and phosphoinositides []. The interaction between gelsolin and tropomyosin modulates actin dynamics []. Gelsolin also plays a role in ciliogenesis []. The structure of gelsolin has been solved []. In humans there are two forms of gelsolin generated by alternative splicing. One is the cytosolic form that has a role in the regulation of the actin cytoskelton [], the other is the secreted form that may be part of the actin scavenging system in the bloodstream []. Mutations in gelsolin gene cause familial amyloidosis of Finnish type (FAF) [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

0 Found In

1 Parent Features

Id Name Short Name Type
IPR007122 Villin/Gelsolin Villin/Gelsolin Family

9 Publications

First Author Title Year Journal Volume Pages
Burtnick LD The crystal structure of plasma gelsolin: implications for actin severing, capping, and nucleation. 1997 Cell 90 661-70
Weeds AG Preparation and characterization of pig plasma and platelet gelsolins. 1986 Eur J Biochem 161 69-76
McGough AM The gelsolin family of actin regulatory proteins: modular structures, versatile functions. 2003 FEBS Lett 552 75-81
Khaitlina S The interaction of gelsolin with tropomyosin modulates actin dynamics. 2013 FEBS J 280 4600-11
Kim J Functional genomic screen for modulators of ciliogenesis and cilium length. 2010 Nature 464 1048-51
Janmey PA Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate. 1987 Nature 325 362-4
Page LJ Ca2+ binding protects against gelsolin amyloidosis. 2004 Biochem Biophys Res Commun 322 1105-10
Yin HL Structure and biosynthesis of cytoplasmic and secreted variants of gelsolin. 1984 J Biol Chem 259 5271-6
Lee WM The extracellular actin-scavenger system and actin toxicity. 1992 N Engl J Med 326 1335-41

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)