InterPro : IPR028760

Name  Ski oncogene Short Name  Ski
Type  Family Description  Ski is involved in oncogenic transformation and enhancement of muscle differentiation by blocking TGF-beta signaling [, ]. Ski binds directly to the Smad3/4 complex and negatively regulates TGF-beta signaling [, , ]. It plays a role in terminal differentiation of skeletal muscle cells, but not in the determination of cells to the myogenic lineage []. Ski is a component of the histone deacetylase complex (HDAC) complex and is required for the transcriptional repression mediated by this complex []. This entry includes v-ski (viral oncogene ski) from the avian Sloan-Kettering retroviruses and its homologue from animals, c-ski []. c-ski can promote cancer progression and is highly expressed in some of solid cancers including leukemia, melanoma, colorectal cancer, gastric cancer and pancreatic cancer []. However, it can also act as a tumour suppressor in some cases [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

0 Found In

1 Parent Features

Id Name Short Name Type
IPR023216 Transcription regulator SKI/SnoN Tscrpt_reg_SKI_SnoN Family

9 Publications

First Author Title Year Journal Volume Pages
Wu JW Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling. 2002 Cell 111 357-67
Takahata M SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells. 2009 J Biol Chem 284 3334-44
Harada J Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation. 2003 J Biol Chem 278 38998-9005
Akiyoshi S c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads. 1999 J Biol Chem 274 35269-77
Colmenares C Activation of the c-ski oncogene by overexpression. 1991 J Virol 65 4929-35
Leong GM Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription. 2001 J Biol Chem 276 18243-8
Nomura T Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor. 1999 Genes Dev 13 412-23
Engert JC Activation of a muscle-specific enhancer by the Ski proto-oncogene. 1995 Nucleic Acids Res 23 2988-94
Wang L c-Ski activates cancer-associated fibroblasts to regulate breast cancer cell invasion. 2013 Mol Oncol 7 1116-28

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)