InterPro : IPR026986

Name  Kinesin-like protein KIF22 (Kid) Short Name  KIF22
Type  Family Description  Kinesin-like protein KIF22 (also known as kinesin-like DNA-binding protein, Kid) is a chromokinesin that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis [, , ]. KIF22 is associated with chromosome arms and plays an important part in producing the polar ejection forces that move chromosome arms toward the spindle equator at metaphase during mitosis []. Its destruction is needed for anaphase chromosome movement []. Depletion of KIF22 caused abnormal chromosome arm orientation, delayed chromosome congression, and sensitised cells to nocodazole []. Defects in KIF22 are the cause of spondyloepimetaphyseal dysplasia with joint laxity, type 2 (SEMDJL2), a bone disease characterised by short stature, distinctive midface retrusion, progressive knee malalignment, generalised ligamentous laxity, and mild spinal deformity [, ].
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Sequence Features

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Proteins

InterPro protein domain ID --> Contigs

 

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6 Publications

First Author Title Year Journal Volume Pages
Min BJ Whole-exome sequencing identifies mutations of KIF22 in spondyloepimetaphyseal dysplasia with joint laxity, leptodactylic type. 2011 Am J Hum Genet 89 760-6
Boyden ED Recurrent dominant mutations affecting two adjacent residues in the motor domain of the monomeric kinesin KIF22 result in skeletal dysplasia and joint laxity. 2011 Am J Hum Genet 89 767-72
Wandke C Human chromokinesins promote chromosome congression and spindle microtubule dynamics during mitosis. 2012 J Cell Biol 198 847-63
Funabiki H The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement. 2000 Cell 102 411-24
Antonio C Xkid, a chromokinesin required for chromosome alignment on the metaphase plate. 2000 Cell 102 425-35
Perez LH Xkid chromokinesin is required for the meiosis I to meiosis II transition in Xenopus laevis oocytes. 2002 Nat Cell Biol 4 737-42



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)